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Correlation between serum content of cytokines and neuropeptides in children with recurrent bronchitis and vertebrobasilar arterial system syndrome

机译：复发性支气管炎儿童细胞因子和神经肽血清含量与椎弓鼠动脉系统综合征的相关性

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摘要

Background. The presence of nervous regulation imbalance in children is a cause of bronchopulmonary pathology with severe clinical course. The study of neuroimmune relationships in children with vertebrobasilar arterial system syndrome and acute bronchitis will allow establishing important elements in the pathogenesis of this combination. Objective: to determine neuroimmune relationships in children with vertebrobasilar arterial system syndrome causing the formation of recurrent acute bronchitis. Materials and methods. We have examined 60 children aged 7 to 12 years. Two groups were formed (30 children each): 1) patients with vertebrobasilar arterial system syndrome and acute bronchitis; 2) children without vertebrobasilar arterial system syndrome and acute bronchitis. Results. The children of group 1 in comparison with the children of group 2 more frequently had a decrease in the phagocytic number (by 56.7 %; p < 0.05), phagocytic index (by 53.3 %; p < 0.05), phagocytosis completeness index (by 66.7 %; p < 0.05), stimulated nitroblue tetrazolium test (by 40.0 %; p < 0.05). When studying adaptive immunity, an increase was detected in the number of group 1 children with elevated serum CD3+ (by 40.0 %; p < 0.05), CD4+ (by 33.4 %; p < 0.05), CD8+ (46.7 %; p < 0.05), CD25+ (83.3 %; p < 0.05) levels, increased serum content of IgG (by 33.3 %; p < 0.05) and IgM (54.3 %; p < 0.05) against the background of a decrease in IgA (by 40.0 %; p < 0.05). Children of group 1 had elevated serum levels of tumor necrosis factor a (by 70.0 %; p < 0.05) and a decrease in interleukin-10 (by 40.0 %; p < 0.05), along with increased concentration of substance P (by 40.0 %; p < 0.05) and a decrease of vasoactive intestinal peptide (by 30.0 %; p < 0.05). Conclusions. In children with the vertebrobasilar arterial system syndrome and acute bronchitis, pro-inflammatory cytokines and neuropeptides predominate in the blood serum, with insufficiency of anti-inflammatory substances.
机译：背景。儿童神经调控性不平衡的存在是严重临床过程的支气管肺病理学的原因。椎体系统动脉系统综合征和急性支气管炎儿童神经影响的关系将允许在这种组合的发病机制中建立重要的元素。目的：确定椎弓鼠动脉系统综合征患儿中的神经影响关系，导致形成复发性急性支气管炎。材料和方法。我们已经审查了7岁至12年的60岁儿童。形成两组（每30名儿童）：1）椎体动脉系统综合征和急性支气管炎的患者; 2）没有椎体动脉系统综合征和急性支气管炎的儿童。结果。第1组的儿童与第2组的儿童相比，吞噬数量减少（56.7％; P <0.05），吞噬指数（按53.3％; P <0.05），吞噬症完整性指数（66.7 ％; P <0.05），刺激硝基唑唑鎓试验（40.0％; P <0.05）。在研究自适应免疫时，在血清CD3 +升高的儿童的数量中检测到增加（40.0％; P <0.05），CD4 +（33.4％; P <0.05），CD8 +（46.7％; P <0.05） ，CD25 +（83.3％; P <0.05）水平，增加IgG血清含量（33.3％; P <0.05）和IgA的背景下的IgM（54.3％; P <0.05）（40.0％; P <0.05）。第1组的儿童血清肿瘤坏死因子A（70.0％; P <0.05）升高，白细胞介素-10降低（40.0％; P <0.05），随着物质p的增加，浓度增加（40.0％） ; p <0.05）和血管活性肠肽的减少（30.0％; P <0.05）。结论。在椎体动物系统综合征和急性支气管炎的儿童中，促炎细胞因子和神经肽在血液血清中占主导地位，具有抗炎物质的不足。

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    L.S. Ovcharenko; T.V. Slutska;

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  • 年度 2018
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  • 正文语种 rus;ukr;eng
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