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Balanced Activation of Striatal Output Pathways by Faster Off-Rate PDE10A Inhibitors Elicits Not Only Antipsychotic-Like Effects But Also Procognitive Effects in Rodents

机译：通过更快的偏移PDE10A抑制剂的平衡激活纹状物输出途径不仅引起抗精神病的效果，而且还引发了靶标的效果，而且还引发了啮齿动物的预诊断效果

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Akina Harada; Nidhi Kaushal; Kazunori Suzuki; Atsushi Nakatani; Konstantin Bobkov; John A Vekich; Joseph P Doyle; Haruhide Kimura;
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1. Balanced Activation of Striatal Output Pathways by Faster Off-Rate PDE10A Inhibitors Elicits Not Only Antipsychotic-Like Effects But Also Procognitive Effects in Rodents [J] . Harada Akina, Kaushal Nidhi, Suzuki Kazunori, The international journal of neuropsychopharmacology . 2020,第2期

机译：通过更快的偏移PDE10A抑制剂的平衡激活纹状物输出途径不仅引起抗精神病的效果，而且还引发了靶标的效果，而且还引发了啮齿动物的预诊断效果
2. PDE10A inhibitors stimulate or suppress motor behavior dependent on the relative activation state of the direct and indirect striatal output pathways [J] . Annemie L. Y. Wellens, Anton A. H. P. Megens, Herman M. R. Hendrickx, Pharmacology Research & Perspectives . 2014,第4期

机译：PDE10A抑制剂取决于直接和间接纹状体输出途径的相对激活状态来刺激或抑制运动行为
3. FTBMT, a Novel and Selective GPR52 Agonist, Demonstrates Antipsychotic-Like and Procognitive Effects in Rodents, Revealing a Potential Therapeutic Agent for Schizophrenia [J] . Nishiyama Keiji, Suzuki Hirobumi, Harasawa Toshiya, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2017,第2期

机译：FTBMT，一种新颖和选择性GPR52激动剂，在啮齿动物中证明了抗精神病药物和预验证效果，揭示了精神分裂症的潜在治疗剂
4. Effects of Tissue Factor Pathway Inhibitor and Antlthrombin on Thrombin Generation in Tissue Factor-actiwated Cord Plasma [C] . G. Cvirn, S. Gallistl, B. Leschnik, Hemophilie-Symposion . 2003

机译：组织因子途径抑制剂和抗细胞间抑制作用对组织因子致脊髓等离子体血栓形成的影响
5. Effects of chronic administration of a D3 dopamine receptor preferring agonist on the Akt/GSK3/3 pathway in striatal brain regions. [D] . Prasad, Sheela. 2016

机译：长期给予首选D3多巴胺受体激动剂对纹状体脑区域Akt / GSK3 / 3途径的影响。
6. Balanced Activation of Striatal Output Pathways by Faster Off-Rate PDE10A Inhibitors Elicits Not Only Antipsychotic-Like Effects But Also Procognitive Effects in Rodents [O] . Akina Harada, Nidhi Kaushal, Kazunori Suzuki, 2020

机译：更快的偏价PDE10A抑制剂可平衡纹状体输出途径的激活不仅引起类鼠类抗精神病药的作用还引起啮齿动物的认知作用。
7. TAK-063, a PDE10A Inhibitor with Balanced Activation of Direct and Indirect Pathways, Provides Potent Antipsychotic-Like Effects in Multiple Paradigms [O] . Kazunori Suzuki, Akina Harada, Hirobumi Suzuki, 2016

机译：TAK-063，PDE10A抑制剂具有平衡的直接和间接途径的激活，提供多种范式的有效的抗精神病效果

Balanced Activation of Striatal Output Pathways by Faster Off-Rate PDE10A Inhibitors Elicits Not Only Antipsychotic-Like Effects But Also Procognitive Effects in Rodents

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