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Discovery of Chromeno4,3-cpyrazol-4(2H)-one Containing Carbonyl or Oxime Derivatives as Potential, Selective Inhibitors PI3Kα

机译：Chromeno的发现4,3- C吡唑-4（2℃） - 一种含有羰基或肟衍生物作为潜在的选择性抑制剂Pi3kα

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Liang Lu; Shao Sha; Kai Wang; Yuan-Heng Zhang; Yan-Dong Liu; Guo-Dong Ju; Baozhong Wang; Hai-Liang Zhu;
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1. Discovery of Chromeno[4,3-c]pyrazol-4(2H)-one Containing Carbonyl or Oxime Derivatives as Potential, Selective Inhibitors PI3Kα [J] . Chemical and Pharmaceutical Bulletin . 2016,第11期

机译：发现含羰基或肟衍生物的Chromeno [4,3-c]吡唑-4（2H）-one作为潜在的选择性抑制剂PI3Kα
2. Discovery and synthesis of a novel series of potent, selective inhibitors of the PI3Kα: 2-alkyl-chromeno[4,3-c]pyrazol-4(2H)-one derivatives [J] . Yong Yin, Xun Wu, Hong-Wei Han, Organic & biomolecular chemistry . 2014,第45期

机译：发现和合成新型的PI3Kα的有效，选择性抑制剂系列：2-烷基-chromeno [4,3-c] pyrazol-4（2H）-one衍生物
3. Discovery of novel quinazolinone derivatives as high potent and selective PI3K delta and PI3K delta/gamma inhibitors [J] . Ma Chen-Chen, Zhang Cheng-Mei, Tang Long-Qian, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2018,第期

机译：发现新型喹唑啉酮衍生物作为高效和选择性PI3Kδ和PI3Kδ/γ抑制剂
4. QSAR modeling and structure based virtual screening of new PI3K/mTOR inhibitors as potential anticancer agents [C] . Jelena Oluic, Katarina Nikolic, Mica Vucicevic International Conference on Medical and Biological Engineering . 2017

机译：基于QSAR建模和基于结构的新PI3K / MTOR抑制剂的虚拟筛选潜在抗癌剂
5. Part One. Synthesis of optically active tryptophan derivatives with potential activity as indoleamine 2,3-dioxygenase inhibitors: An approach via asymmetric catalytic hydrogenation. Part Two. Design, synthesis and pharmacology of selective ligands for alpha1-containing GABA(A)/benzodiazepine receptor subtypes: SAR studies of beta-carbolines at positions -3 and -6 and their corresponding bivalent ligands. Part Three. First enantiospecific total synthesis of the important biogenetic intermediates, (+)-polyneuridine and (+)-polyneuridine aldehyde, as well as 16-epi-vellosimine and macusine A. [D] . Yin, Wenyuan. 2007

机译：第一部分。具有吲哚胺2,3-二加氧酶抑制剂潜在活性的旋光色氨酸衍生物的合成：一种通过不对称催化氢化的方法。第二部分。含α1的GABA（A）/苯并二氮杂receptor受体亚型的选择性配体的设计，合成和药理作用：位于-3和-6位的β-咔啉及其相应的二价配体的SAR研究。第三部分。重要生物遗传中间体，（+）-聚神经氨酸和（+）-聚神经氨酸醛，以及16-表-维西辛和Macusine A的首次对映体全合成。
6. Discovery of Novel 5-(Piperazine-1-carbonyl)pyridin-2(1H)-one Derivatives as Orally eIF4A3-Selective Inhibitors [O] . Ryo Mizojiri, *, Daisuke Nakata, 2017

机译：新型5-（哌嗪-1-羰基）吡啶-2（1H）-一衍生物作为口服eIF4A3选择性抑制剂的发现
7. l-Aminoacyl-triazine Derivatives Are Isoform-Selective PI3Kβ Inhibitors That Target Nonconserved Asp862 of PI3Kβ [O] . Jo-Anne Pinson, Zhaohua Zheng, Michelle S. Miller, 2012

机译：L-氨基酰基 - 三嗪衍生物是同种型选择性PI3Kβ抑制剂，其靶向PI3Kβ的非经均衡的ASP862

Discovery of Chromeno4,3-cpyrazol-4(2H)-one Containing Carbonyl or Oxime Derivatives as Potential, Selective Inhibitors PI3Kα

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