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Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope

机译：腺嘌呤碱基编辑器mRNA的化学修饰和指导RNA扩大其应用范围

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Cas9 base editors are promising tools for correcting pathogenic single nucleotide mutations. Here the authors chemically modify mRNA encoding the editor and the gRNA to enhance editing and broaden its application.

机译：CAS9基础编辑器是校正致病性单核苷酸突变的有希望的工具。在这里，作者化学修改编码编辑器和GRNA的mRNA，以增强编辑并拓宽其应用。

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作者
Tingting Jiang; Jordana M. Henderson; Kevin Coote; Yi Cheng; Hillary C. Valley; Xiao-Ou Zhang; Qin Wang; Luke H. Rhym; Yueying Cao; Gregory A. Newby; Hermann Bihler; Martin Mense; Zhiping Weng; Daniel G. Anderson; Anton P. McCaffrey; David R. Liu; Wen Xue;
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年度 2020
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原文格式 PDF
正文语种 eng
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1. Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope [J] . Tingting Jiang, Jordana M. Henderson, Kevin Coote, Nature Communications . 2020,第1期

机译：腺嘌呤碱基编辑器mRNA的化学修饰和指导RNA扩大其应用范围
2. Expanding the Chemical Scope of RNA Base Editors [J] . Rauch Simone, Dickinson Bryan C. Biochemistry . 2019,第34期

机译：扩大RNA基础编辑器的化学范围
3. Genome-wide target specificity of CRISPR RNA-guided adenine base editors. [J] . Daesik Kim, Da-Eun Kim, Gyeorae Lee, Nature biotechnology . 2019,第4期

机译：CRISPR RNA引导腺嘌呤基础编辑器的基因组目标特异性。
4. Mobile application to induce lifestyle modifications in type 2 diabetic patients: prototype based on international guidelines [C] . M. Garcia-Jaramillo, J.S. Delgado, F. Leon-Vargas International symposium on medical information processing and analysis . 2015

机译：用于诱导2型糖尿病患者生活方式改变的移动应用程序：基于国际准则的原型
5. Production and Chemical Modification of Unsaturated Poly[( R)-3-hydroxyalkanoates] for Expanded Physical Properties and Applications [D] . Levine, Alex C. 2016

机译：不饱和聚[（R）-3-羟基链烷酸酯]的生产和化学改性，以扩大物理性能和应用
6. An adenine base editor with expanded targeting scope using SpCas9‐NGv1 in rice [O] . Katsuya Negishi, Hidetaka Kaya, Kiyomi Abe, -1

机译：在水稻中使用SpCas9-NGv1的腺嘌呤碱基编辑器可扩展靶向范围
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Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope

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