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Synthesis and anti-HCV activity of β-d-2′-deoxy-2′-α-chloro-2′-β-fluoro and β-d-2′-deoxy-2′-α-bromo-2′-β-fluoro nucleosides and their phosphoramidate prodrugs

机译：β-D-2'-脱氧-2'-α-氯-2'-β-氟和β-D-2'-脱氧-2'-α-Bromo-2'-β的合成和抗HCV活性-fluoro核苷及其磷酸氨基甲酸的前药

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Reuben Ovadia; Ahmed Khalil; Hao Li; Coralie De Schutter; Seema Mengshetti; Shaoman Zhou; Leda Bassit; Steven J. Coats; Franck Amblard; Raymond F. Schinazi;
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1. Synthesis and anti-HCV activity of beta-D-2 '-deoxy-2 '-alpha-chloro-2 '-beta-fluoro and beta-D-2 '-deoxy-2 '-alpha-bromo-2 '-beta-fluoro nucleosides and their phosphoramidate prodrugs [J] . Ovadia Reuben, Khalil Ahmed, Li Hao, Bioorganic and medicinal chemistry . 2019,第4期

机译：β-D-2'-丁氧基-2' - 氯-2'-β-氟和β-D-2'-丁氧基-2'-alpha-Bromo-2'-Beta的合成和抗HCV活性 -fluoro核苷及其氨基磷酸酯前药
2. Synthesis and biological evaluation of a novel β-D-2′-deoxy-2′-α-fluoro-2′-β- C -(fluoromethyl)uridine phosphoramidate prodrug for the treatment of hepatitis C virus infection [J] . Ertong Li, Yafeng Wang, Wenquan Yu, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2018,第期

机译：新型β-D-2'-脱氧-2'-α-Fluoro-2'-β-C - （氟甲基）尿苷氨基磷酸产物治疗丙型肝炎病毒感染的合成与生物学评价
3. Synthesis of 5′-methylene-phosphonate furanonucleoside prodrugs: Application to D-2′-deoxy-2′-α-fluoro-2′-β-C-methyl nucleosides [J] . Pradere U., Amblard F., Coats S.J., Organic letters . 2012,第17期

机译：5'-亚甲基膦酸酯呋喃核苷前药的合成：在D-2'-脱氧-2'-α-氟-2'-β-C-甲基核苷中的应用
4. Characterization of Antisense Oligonucleotides Comprising 2'-Deoxy-2'-Fluoro-β-D-Arabinonucleic Acid (FANA) Specificity, Potency, and Duration of Activity [C] . NICOLAY FERRARI, DENIS BERGERON, ANNA-LISA TEDESCHI, Oligonucleotide Therapeutics Society . 2006

机译：反义寡核苷酸的表征包含2'-脱氧-2'-氟-β-D-亚丙核酸（FANA）特异性，效力和活性持续时间的
5. Part I: Synthesis of 2'-Fluoro-2',3'-Dideoxynucleosides as Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase. Part II: Synthesis of Cyclobutyl Phosphonate and Phosphoramidate Prodrugs for Inhibition of HIV Reverse Transcriptase [D] . Neuman, Annette Welty 2013

机译：第一部分：2'-Fluoro-2'，3'-Dideoxynucleosides的合成作为丙型肝炎病毒RNA依赖性RNA聚合酶的抑制剂。第二部分：抑制HIV逆转录酶的膦酸环丁酯和氨基磷酸酯前药的合成
6. Synthesis and anti-HCV activity of a series of β-D-2′-deoxy-2′-dibromo nucleosides and their corresponding phosphoramidate prodrugs [O] . Zhe Chen, Bryan D. Cox, Ethel C. Garnier-Amblard, -1

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7. Synthesis of 5′-Methylene-Phosphonate Furanonucleoside Prodrugs: Application to D-2′-Deoxy-2′-α-fluoro-2′-β-C-methyl Nucleosides [O] . Ugo Pradere, Franck Amblard, Steven J. Coats, 2012

机译：合成5'-亚甲基膦酸呋喃核苷前药：在D-2'-脱氧-2'-α-氟-2'-β-C-甲基核苷的应用
8. Discovery and Synthesis of GS-5734, a Phosphoramidate Prodrug of a Pyrrolo[2,1 f][triazin-4-amino] Adenine C-Nucleoside for the Treatment of Ebola and Emerging Viruses. [R] . 2017

机译：发现和合成Gs-5734，一种吡咯并[2,1 f] [三嗪-4-氨基]腺嘌呤C-核苷的氨基磷酸酯前药，用于治疗埃博拉病毒和新发病毒。

Synthesis and anti-HCV activity of β-d-2′-deoxy-2′-α-chloro-2′-β-fluoro and β-d-2′-deoxy-2′-α-bromo-2′-β-fluoro nucleosides and their phosphoramidate prodrugs

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