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Ursolic Acid Attenuates Hepatic Steatosis, Fibrosis, and Insulin Resistance by Modulating the Circadian Rhythm Pathway in Diet-Induced Obese Mice

机译:通过调节饮食诱导的肥胖小鼠的昼夜节律途径,熊糖酸衰减肝脏脂肪变性,纤维化和胰岛素抵抗力

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摘要

The aim of the current study was to elucidate the effects of long-term supplementation with dietary ursolic acid (UR) on obesity and associated comorbidities by analyzing transcriptional and metabolic responses, focusing on the role of UR in the modulation of the circadian rhythm pathway in particular. C57BL/6J mice were divided into three groups and fed a normal diet, high-fat diet, or high-fat + 0.05% (w/w) UR diet for 16 weeks. Oligonucleotide microarray profiling revealed that UR is an effective regulator of the liver transcriptome, and canonical pathways associated with the “circadian rhythm„ and “extracellular matrix (ECM)⁻receptor interactions„ were effectively regulated by UR in the liver. UR altered the expression of various clock and clock-controlled genes (CCGs), which may be linked to the improvement of hepatic steatosis and fibrosis via lipid metabolism control and detoxification enhancement. UR reduced excessive reactive oxygen species production, adipokine/cytokine dysregulation, and ECM accumulation in the liver, which also contributed to improve hepatic lipotoxicity and fibrosis. Moreover, UR improved pancreatic islet dysfunction, and suppressed hepatic gluconeogenesis, thereby reducing obesity-associated insulin resistance. Therapeutic approaches targeting hepatic circadian clock and CCGs using UR may ameliorate the deleterious effects of diet-induced obesity and associated complications such as hepatic fibrosis.
机译:目前的研究目的是通过分析转录和代谢反应来阐明长期补充与饮食熊酸(UR)对肥胖症和相关的合并症的影响,重点是您在昼夜节律途径调制中的作用特定。将C57BL / 6J小鼠分为三组,并喂养正常饮食,高脂饮食,或高脂肪+ 0.05%(W / W)饮食16周。寡核苷酸微阵列分析表明,UR是肝脏转录组的有效调节剂,并且在肝脏中,UR有效地调节与“昼夜节律”和“细胞外基质(ECM)⁻中的相互作用”相关的规范途径。你改变了各种时钟和时钟控制基因(CCG)的表达,其可以通过脂质代谢对照和排毒增强改善肝脏脂肪变性和纤维化。 UR降低过量的反应性氧物种生产,脂肪口/细胞因子诱导和肝脏中的ECM积累,这也有助于改善肝脂毒性和纤维化。此外,您改善了胰岛功能障碍和抑制肝葡糖生成,从而降低了肥胖相关的胰岛素抵抗力。靶向肝昼夜钟表和CCG的治疗方法可能会改善饮食诱导的肥胖症和相关并发症如肝纤维化的有害影响。

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