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Discovery of Potent Antivirals against Amantadine-Resistant Influenza A Viruses by Targeting the M2-S31N Proton Channel

机译：通过靶向M2-S31N质子通道，对含余氨基抗性流感的有效抗病毒体进行发现

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Fang Li; Chunlong Ma; Yanmei Hu; Yuanxiang Wang; Jun Wang;
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1. Discovery of M2 channel blockers targeting the drug-resistant double mutants M2-S31N/L26I and M2-S31N/V27A from the influenza A viruses [J] . Musharrafieh Rami, Ma Chunlong, Wang Jun European journal of pharmaceutical sciences . 2020,第期

机译：发现靶向耐药双突变体M2-S31N / L26I和来自流感病毒的M2-S31N / V27A的M2通道阻断剂
2. In Vitro Pharmacokinetic Optimizations of AM2-S31N Channel Blockers Led to the Discovery of Slow-Binding Inhibitors with Potent Antiviral Activity against Drug-Resistant Influenza A Viruses [J] . Yuanxiang Wang, Yanmei Hu, Shuting Xu, Journal of Medicinal Chemistry . 2018,第3期

机译：体外药代动力学优化AM2-S31N通道阻断器导致对耐药性流感病毒的有效抗病毒活性的缓慢结合抑制剂的发现
3. Flipping in the Pore: Discovery of Dual Inhibitors That Bind in Different Orientations to the Wild-Type versus the Amantadine-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel [J] . Yibing Wu, Belgin Canturk, Hyunil Jo, Journal of the American Chemical Society . 2014,第52期

机译：毛孔翻转：发现两种抑制剂结合了不同的方向，它们与甲型流感病毒M2质子通道的抗金刚烷胺的野生型和抗金刚烷胺S31N突变体结合
4. Solid-state ~(15)N-NMR Investigations on the pH dependent Conformation of Trp-41 of the M2 Proton Channel of Influenza A Virus; [C] . RAIKER WITTER, RIQIANG FU, CONGGANG LI, Advances in biomedical research . 2010

机译：甲型流感病毒M2质子通道Trp-41的pH依赖性构象的固态〜（15）N-NMR研究；
5. Discovery and analysis of potential antivirals targeting the nonstructural 3 helicase of hepatitis C and dengue viruses. [D] . Sweeney, Noreena L. 2015

机译：发现和分析针对丙型肝炎和登革热病毒的非结构性3解旋酶的潜在抗病毒药。
6. Discovery of potent antivirals against amantadine-resistant influenza A viruses by targeting the M2-S31N proton channel [O] . Fang Li, Chunlong Ma, Yanmei Hu, -1

机译：通过靶向M2-S31N质子通道发现抗金刚烷胺抗A型流感病毒的有效抗病毒药
7. Discovery of Potent Antivirals against Amantadine-Resistant Influenza A Viruses by Targeting the M2-S31N Proton Channel [O] . -1

机译：通过靶向M2-S31N质子通道，对含余氨基抗性流感的有效抗病毒体进行发现

Discovery of Potent Antivirals against Amantadine-Resistant Influenza A Viruses by Targeting the M2-S31N Proton Channel

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