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The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression

机译：双MTOR抑制剂AZD2014和PAN-PIM抑制剂AZD1208的新组合抑制了通过HSF途径抑制急性髓性白血病的生长

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Masako Harada; Juliana Benito; Shinichi Yamamoto; Surinder Kaur; Dirim Arslan; Santiago Ramirez; Rodrigo Jacamo; Leonidas Platanias; Hiromichi Matsushita; Tsutomu Fujimura; Saiko Kazuno; Kensuke Kojima; Yoko Tabe; Marina Konopleva;
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1. Protein profiling identifies mTOR pathway modulation and cytostatic effects of Pim kinase inhibitor, AZD1208, in acute myeloid leukemia [J] . Chen Lisa S., Yang Ji-Yeon, Liang Han, Leukemia and lymphoma . 2016,第12期

机译：蛋白质谱分析鉴定了pIM激酶抑制剂AZD1208在急性髓细胞白血病中的mTOR途径调节和细胞抑制作用
2. Inhibition of mTOR pathway sensitizes acute myeloid leukemia cells to Aurora inhibitors by suppression of glycolytic metabolism [J] . LiuL.-L., LongZ.-J., WangL.-X., Molecular cancer research: MCR . 2013,第11期

机译：抑制mTOR途径通过抑制糖酵解代谢使急性髓性白血病细胞对Aurora抑制剂敏感
3. The PI3K/AKT Pathway Inhibitor ISC-4 Induces Apoptosis and Inhibits Growth of Leukemia in Preclinical Models of Acute Myeloid Leukemia [J] . Charyguly Annageldiyev, Su-Fern Tan, Shreya Thakur, Frontiers in Oncology . 2020,第4期

机译：PI3K / AKT途径抑制剂ISC-4诱导细胞凋亡并抑制白血病在急性髓性白血病临床前模型中的生长
4. Azanudeoside DNA Methyltransferase Inhibitor Drugs: Update on Clinical Applications in Myelodysplastic Syndromes and Acute Myeloid Leukemia [C] . Michael Lubbert, Michael Daskalakis, Philipp N. Ser, Weissenburg Symposium Biriciana . 2016

机译：硫代稳产苷DNA甲基转移酶抑制剂药物：更新骨髓增生综合征和急性髓性白血病的临床应用
5. Clinical Pharmacokinetics of the Novel Combination of BEZ235, PI3K/mTOR Inhibitor, and Everolimus, mTOR Inhibitor: Phase I Clinical Studies and Non-Clinical Mechanistic Assessment [D] . Moorthy, Ganesh P. 2015

机译：BEZ235，PI3K / mTOR抑制剂和依维莫司，mTOR抑制剂的新型组合的临床药代动力学：I期临床研究和非临床机制评估
6. The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression [O] . Masako Harada, Juliana Benito, Shinichi Yamamoto, 2015

机译：mTOR抑制剂AZD2014和pan-PIM抑制剂AZD1208的新型组合通过HSF途径抑制来抑制急性髓细胞性白血病的生长
7. Protein profiling identifies mTOR pathway modulation and cytostatic effects of Pim kinase inhibitor, AZD1208, in acute myeloid leukemia [O] . Lisa S. Chen, Ji-Yeon Yang, Han Liang, 2016

机译：蛋白质分析鉴定了PIM激酶抑制剂，AZD1208，急性髓性白血病的MTOR途径调节和细胞抑制作用

The novel combination of dual mTOR inhibitor AZD2014 and pan-PIM inhibitor AZD1208 inhibits growth in acute myeloid leukemia via HSF pathway suppression

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