首页> 外文OA文献 >Structure selectivity relationship studies of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(4′-pyridyl)carboxamidomorphinan derivatives toward the development of the mu opioid receptor antagonists

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Structure selectivity relationship studies of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(4′-pyridyl)carboxamidomorphinan derivatives toward the development of the mu opioid receptor antagonists

机译：17-环丙基甲基-3,14β-二羟基-4,5α-环氧-6β - （4'-吡啶基）甲酰胺吗啡甘蔗衍生物对Mu阿片受体拮抗剂的发展的结构选择性关系研究

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Yunyun Yuan; Orgil Elbegdorj; Jianyang Chen; Shashidhar K. Akubathini; Irina O. Beletskaya; Dana E. Selley; Yan Zhang;
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年度 2011
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1. Structure selectivity relationship studies of 17-cyclopropylmethyl-3, 14β-dihydroxy-4,5α-epoxy-6β-[(4'-pyridyl)carboxamido]morphinan derivatives toward the development of the mu opioid receptor antagonists [J] . YuanY., ElbegdorjO., ChenJ., Bioorganic and Medicinal Chemistry Letters . 2011,第18期

机译：17-环丙基甲基-3，14β-二羟基-4,5α-环氧-6β-[（4'-吡啶基）羧酰胺基]吗啡喃衍生物对mu阿片受体拮抗剂发展的结构选择性关系研究
2. Design, synthesis, and biological evaluation of 17-cyclopropylmethyl-3, 14β-dihydroxy-4,5α-epoxy-6β-[(4′-pyridyl)carboxamido] morphinan derivatives as peripheral selective μ opioid receptor agents [J] . Yuan Y., Elbegdorj O., Chen J., Journal of Medicinal Chemistry . 2012,第22期

机译：设计，合成和生物学评价17-环丙基甲基-3，14β-二羟基-4,5α-环氧-6β-[（4'-吡啶基）羧酰胺基]吗啡喃衍生物作为外周选择性μ阿片受体的药物
3. Structure activity relationship studies of 17-cyclopropylmethyl-3,14β- dihydroxy-4,5α-epoxy-6α-(isoquinoline-3′-carboxamido) morphinan (NAQ) analogues as potent opioid receptor ligands: Preliminary results on the role of electronic characteristics for affinity and function [J] . YuanY., ElbegdorjO., BeletskayaI.O., Bioorganic and Medicinal Chemistry Letters . 2013,第18期

机译：作为有效的阿片受体配体的17-环丙基甲基-3,14β-二羟基-4,5α-环氧-6α-（异喹啉-3'-羧酰胺基）吗啡喃（NAQ）类似物的结构活性关系研究：关于电子特性作用的初步结果为了亲和力和功能
4. Structure-Activity Relationships of the Peptide Kappa Opioid Receptor Antagonist Zyklophin [C] . Anand A. Joshi, Thomas F. Murray, Jane V. Aldrich American Peptide Symposium . 2011

机译：肽Kappa阿片受体拮抗剂Zyklophin的结构 - 活性关系
5. Selective GLP-1 receptor antagonists and glucagon/GLP-1 co-agonists discovered through an investigation into the structure-activity relationship in glucagon-related peptides. [D] . Patterson, James T. 2011

机译：通过研究胰高血糖素相关肽的结构-活性关系，发现了选择性的GLP-1受体拮抗剂和胰高血糖素/ GLP-1共激动剂。
6. Structure Selectivity Relationship Studies of 17-Cyclopropylmethyl-314β-dihydroxy-45α-epoxy-6β-(4-pyridyl)carboxamidomorphinan Derivatives Toward the Development of the Mu Opioid Receptor Antagonists [O] . Yunyun Yuan, Orgil Elbegdorj, Jianyang Chen, -1

机译：17-环丙基甲基-314β-二羟基-45α-环氧-6β - （4-吡啶基）甲酰胺吗啡甘蔗衍生物对Mu阿片受体拮抗剂的发展的结构选择性关系研究
7. Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(4′-pyridyl)carboxamidomorphinan (NAP) Derivatives as μ/κ Opioid Receptor Dual Selective Ligands [O] . Yi Zheng, Samuel Obeng, Huiqun Wang, 2019

机译：第三代17-环丙基甲基-3,14β-二羟基-4,5α-环氧-6β - （4'-吡啶基）羧酰胺吗啡甘蔗（NAP）衍生物的设计，合成和生物学评价为μ/κ阿片受体受体双重选择性配体

Structure selectivity relationship studies of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(4′-pyridyl)carboxamidomorphinan derivatives toward the development of the mu opioid receptor antagonists

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