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Clinical and kinomic analysis identifies peripheral blood mononuclear cells as a potential pharmacodynamic biomarker in metastatic renal cell carcinoma patients treated with sunitinib

机译：临床和护版分析将外周血单核细胞鉴定为桑顿治疗的转移性肾细胞癌患者中的潜在药物动力学生物标志物

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International audience

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Gaёlle Noé; Audrey Bellesoeur; Audrey Thomas-Schoemann; Savithri Rangarajan; Faris Naji; Alicja Puszkiel; Olivier Huillard; Nathaniel Saidu; Lisa Golmard; Jerome Alexandre; Francois Goldwasser; Benoit Blanchet; Michel Vidal;
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专利

1. Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: modulation of VEGF and VEGF-related proteins [J] . Samuel E DePrimo, Carlo L Bello, John Smeraglia, Journal of Translational Medicine . 2007,第1期

机译：舒尼替尼在转移性肾细胞癌患者中药理活性的循环蛋白生物标志物：VEGF和VEGF相关蛋白的调节
2. Sorafenib, but not sunitinib, induces regulatory T cells in the peripheral blood of patients with metastatic renal cell carcinoma [J] . Fl?rckenA., TakvorianA., VanLessenA., Anti-cancer drugs . 2012,第3期

机译：索拉非尼而非舒尼替尼可诱导转移性肾细胞癌患者外周血中的调节性T细胞
3. Validation of VEGFR1 rs9582036 as predictive biomarker in metastatic clear-cell renal cell carcinoma patients treated with sunitinib [J] . Beuselinck Benoit, Jean-Baptiste Johnny, Schoffski Patrick, BJU international . 2016,第6期

机译：在舒尼替尼治疗的转移性透明细胞肾细胞癌患者中，VEGFR1 rs9582036作为预测性生物标志物的验证
4. When to Treat Metastatic Renal Cell Carcinoma Comorbidities, Systemic Therapy, and Active Surveillance in Metastatic Kidney Cancer [C] . Brian I. Rini Genitourinary Cancers Symposium . 2012

机译：何时治疗转移性肾细胞癌的组合，全身治疗，以及在转移性肾癌中的活跃监测
5. IgE anti-HIV-1 in serum of HIV-1 infected children inhibits HIV-1 production in vitro and IgE mediates cytotoxicity against lymphoma cells expressing HIV-1 and peripheral blood mononuclear cells from an HIV-1 seropositive patient [D] . Bluth, Martin Heath. 1997

机译：HIV-1感染儿童血清中的IgE抗HIV-1抑制了HIV-1的体外产生，IgE介导了对HIV-1血清反应阳性患者表达HIV-1的淋巴瘤细胞和外周血单核细胞的细胞毒性
6. Clinical and kinomic analysis identifies peripheral blood mononuclear cells as a potential pharmacodynamic biomarker in metastatic renal cell carcinoma patients treated with sunitinib [O] . Gaёlle Noé, Audrey Bellesoeur, Audrey Thomas-Schoemann, 2016

机译：临床和动力学分析鉴定了舒尼替尼治疗的转移性肾细胞癌患者外周血单个核细胞是潜在的药效生物标志物
7. Clinical and kinomic analysis identifies peripheral blood mononuclear cells as a potential pharmacodynamic biomarker in metastatic renal cell carcinoma patients treated with sunitinib [O] . Noé Gaёlle, Bellesoeur Audrey, Thomas-Schoemann Audrey, 2016

机译：临床和动力学分析鉴定了舒尼替尼治疗的转移性肾细胞癌患者外周血单个核细胞是潜在的药效生物标志物

Clinical and kinomic analysis identifies peripheral blood mononuclear cells as a potential pharmacodynamic biomarker in metastatic renal cell carcinoma patients treated with sunitinib

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