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Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol

机译：发现有效的HMG-COA还原酶降解剂，消除了他汀类药物诱导的还原酶积累和降低胆固醇

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Shi-You Jiang; Hui Li; Jing-Jie Tang; Jie Wang; Jie Luo; Bing Liu; Jin-Kai Wang; Xiong-Jie Shi; Hai-Wei Cui; Jie Tang; Fan Yang; Wei Qi; Wen-Wei Qiu; Bao-Liang Song;
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1. Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol [J] . Shi-You Jiang, Hui Li, Jing-Jie Tang, Nature Communications . 2018,第1期

机译：发现有效的HMG-CoA还原酶降解剂，可消除他汀类药物诱导的还原酶蓄积并降低胆固醇
2. RPR 107393, a potent squalene synthase inhibitor and orally effective cholesterol-lowering agent: comparison with inhibitors of HMG-CoA reductase. [J] . Amin D, Rutledge RZ, Needle SN, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 1997,第2期

机译：RPR 107393，一种有效的角鲨烯合酶抑制剂和口服有效的降胆固醇剂：与HMG-CoA还原酶抑制剂的比较。
3. Cholesterol-Dependent Degradation of Squalene Monooxygenase, a Control Point in Cholesterol Synthesis beyond HMG-CoA Reductase. [J] . Gill S, Stevenson J, Kristiana I, Cell metabolism . 2011,第3期

机译：角鲨烯单加氧酶的胆固醇依赖性降解，角鲨烯单加氧酶是胆固醇合成中超过HMG-CoA还原酶的控制点。
4. Statin Inhibition of HMG-CoA Reductase by Quantum Biochemistry Computations [C] . Fulco U.L., Albuquerque E.L., da Silva L.R. Southern Biomedical Engineering Conference . 2013

机译：量子生化计算对HMG-CoA还原酶的他汀类抑制剂
5. Computational studies on the mechanism of HMG-CoA reductase and the Grignard SRN1 reaction. [D] . Haines, Brandon E. 2014

机译：HMG-CoA还原酶与Grignard SRN1反应机理的计算研究。
6. Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol [O] . Shi-You Jiang, Hui Li, Jing-Jie Tang, -1

机译：发现有效的HMG-CoA还原酶降解剂可消除他汀类药物诱导的还原酶积聚并降低胆固醇
7. Cholesterol-Dependent Degradation of Squalene Monooxygenase, a Control Point in Cholesterol Synthesis beyond HMG-CoA Reductase [O] . Gill Saloni, Stevenson Julian, Kristiana Ika, 2011

机译：角鲨烯单加氧酶的胆固醇依赖性降解，角鲨烯单加氧酶是HMG-CoA还原酶以外的胆固醇合成控制点
8. Effects of HMG-COA Reductase Inhibitor Therapy on LDL Cholesterol Blood Levels inHyperlipidemia: A Longitudinal Retrospective Anlaysis Using a Department of Defense Integrated Database [R] . Lee-Ziegler, C. L. 1998

机译：HmG-COa还原酶抑制剂治疗对高脂血症LDL胆固醇血液水平的影响：纵向回顾性分析使用国防部综合数据库

Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol

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