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Combined use of subclinical hydroxyurea and CHK1 inhibitor effectively controls melanoma and lung cancer progression, with reduced normal tissue toxicity compared to gemcitabine

机译：联合使用亚临床羟基脲和CHK1抑制剂有效控制黑素瘤和肺癌进展，与吉西滨相比，正常组织毒性降低

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Zay Yar Oo; Martina Proctor; Alexander J. Stevenson; Deborah Nazareth; Madushan Fernando; Sheena M. Daignault; Catherine Lanagan; Sebastian Walpole; Vanessa Bonazzi; Dubravka Škalamera; Cameron Snell; Nikolas K. Haass; Jill E. Larsen; Brian Gabrielli;
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1. Combined use of subclinical hydroxyurea and CHK1 inhibitor effectively controls melanoma and lung cancer progression, with reduced normal tissue toxicity compared to gemcitabine [J] . Zay Yar Oo, Martina Proctor, Alexander J. Stevenson, Molecular oncology. . 2019,第7期

机译：与吉西他滨相比，亚临床羟基脲和CHK1抑制剂的联合使用可有效控制黑色素瘤和肺癌的进展，同时降低正常组织毒性
2. PRONTOX – proton therapy to reduce acute normal tissue toxicity in locally advanced non-small-cell lung carcinomas (NSCLC): study protocol for a randomised controlled trial [J] . Sebastian Zschaeck, Monique Simon, Steffen L?ck, Trials . 2016,第1期

机译：PRONTOX –质子疗法可降低局部晚期非小细胞肺癌（NSCLC）的急性正常组织毒性：一项随机对照试验的研究方案
3. Phase II randomized study comparing the toxicity profile of gemcitabine plus cisplatin with gemcitabine plus oral etoposide in the treatment of advanced non-small cell lung cancer. [J] . Mok TS, Lam KC, Lee C, Oncology: International Journal of Cancer Research and Treatment . 2005,第4a6期

机译：II期随机研究比较了吉西他滨加顺铂与吉西他滨加口服依托泊苷对晚期非小细胞肺癌的毒性作用。
4. The Combination of Clinical, Dose-Related and Imaging Features Helps Predict Radiation-Induced Normal-Tissue Toxicity in Lung-cancer Patients -- An in-silico Trial Using Machine Learning Techniques [C] . Nalbantov G., Dekker A., De Ruysscher D., Machine Learning and Applications and Workshops (ICMLA), 2011 10th International Conference on . 2011

机译：临床，剂量相关和影像学特征的结合可帮助预测肺癌患者放射诱发的正常组织毒性-使用机器学习技术的计算机模拟试验
5. Combined use of subclinical hydroxyurea and CHK1 inhibitor effectively controls melanoma and lung cancer progression with reduced normal tissue toxicity compared to gemcitabine [O] . Zay Yar Oo, Martina Proctor, Alexander J. Stevenson, 2019

机译：与吉西他滨相比亚临床羟基脲和CHK1抑制剂的联合使用可有效控制黑色素瘤和肺癌的进展同时降低正常组织毒性
6. P1007Aortic root diameters and aortic regurgitation in hypertensive patients and normal subjectsP1008Ultrasonic assessment of backscatter signal intensity of the right ventricle in patients with arterial hypertension as a method of measuring alterations of myocardiumP1009Speckle strain echocardiography for the evaluation of left ventricular dyssynchrony in patients with severe lung diseases and pulmonary hypertensionP1010Impaired left ventricular ejection fraction in a cohort of systemic sclerosis patients: clinical and echocardiographic characteristicsP1011Prognostic role of subclinical left ventricular systolic dysfunction evaluated using strain imaging by speckle-tracking echocardiographyP1012Inferior vena cava diameter is a strong and practical marker of physical activity and fitnessP1013When the heart works for two: morphologic and functional adaptation during pregnancyP1014Extensive use of lung ultrasound in pediatric cardiac surgery: preliminary experienceP1015Asymptomatic delayed right ventricular perforation by cardiac implantable electronic devices lead, echocardiographic featuresP1016Novel echocardiographic prognostic markers for cardiac tamponade in patients with large malignant pericardial effusions. A paradigm shift from flow to tissue imagingP1017Doppler echocardiographic parameters as a marker of cardiac tamponadeP1018Sigmoid septum as a marker of elongation of thoracic aorta caused by progression of atherosclerosisP1019Carotid artery atherosclerosis and stiffness: comparison of different metabolic measuresP1020Feasibility of triple imaging vasodilator stress echo in patients with suspected coronary artery diseaseP1022The use of combined echo and cardio-pulmonary stress for discriminating cardiac problems from de-conditioning in patients with dyspneaP1023Long-term prognosis of a stress echocardiography in patients after successful primary percutaneous intervention and incomplete revascularization of non-culprit lesionsP1024Diastolic exercise stress echo can unmask diastolic dysfunction in type 2 diabetes, a five-year follow-up studyP1025Diabetes mellitus is the major limitation for diagnosis of coronary artery disease assessed by semisupine ergometer stress echocardiographyP1026Longitudinal changes of atherosclerotic features in the aorta on transcatheter aortic valve implantation using transesophageal echocardiographyP1027Severe aortic stenosis: comparison between effective and anatomical aortic?valvular area by two and three dimension transesophageal ecocardiographyP1028Region growing method provides better left ventricular volume and cardaic output measuringP10293 dimensional echocardiographic evaluation of mitral valve geometry in patients with secondary and primary mitral regurgitationP1030The impact of adjustable region of interest on ventricular strain measurements and arrhythmic risk assessment in patients with hypertrophic cardiomyopathyP1031Left ventricular strain at presentation predicts long-term outcome in ALCAPA patientsP1032Global atrial-ventricular strain as a new index of subclinical left heart dysfunction in hypertensive and diabetic patients [O] . O. Vriz, S. Ivanov, M. Szulik, 2016

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Combined use of subclinical hydroxyurea and CHK1 inhibitor effectively controls melanoma and lung cancer progression, with reduced normal tissue toxicity compared to gemcitabine

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