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Performance and Tolerability of a New Topical Dexpanthenol-Containing Emollient Line in Subjects with Dry Skin: Results from Three Randomized Studies

机译:含有干燥皮肤的受试者含含新宠物葡萄亮润肤系的性能和耐受性:三项随机研究的结果

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摘要

Three studies were conducted with three new dexpanthenol-containing emollients containing increasing lipid contents (Emollients 1–3) to assess their performances in healthy adults with dry skin. All three studies (N = 42 each) followed virtually the same design. A single skin application of the study product was performed followed by once-daily usage. Skin hydration, transepidermal water loss (TEWL), skin biomechanical properties, and lipid content of the stratum corneum (SC) were regularly assessed over the 28-day study period; a subset (N = 22) underwent a sodium lauryl sulfate (SLS) challenge prior to product application. All three emollients were well tolerated and showed good performances with only minor differences in instrumental measurements. After single and prolonged once-daily applications of Emollients 1–3 to dry skin and dry SLS-damaged skin, skin hydration significantly increased from baseline (BL) (by 38.1–72.4% in unchallenged skin, p < 0.001 for all three). This was paralleled by significant increases in skin elasticity parameters. Usage of Emollients 1 and 3 caused increases from BL in SC cholesterol (by 9.8–12.5%, p < 0.05 for both) and SC free fatty acid levels (by 3.7–26.3%, p < 0.05 for both) at the end of the study. No sustained effects on TEWL were recorded. Our findings support the once-daily use of all three emollients in adults with dry skin.
机译:用含有增加的脂质含量(润肤剂1-3)的含有三种含新的甲吡喃酚润肤剂进行三项研究,以评估其在健康成年人中的性能。所有三项研究(每个第n = 42)遵循几乎相同的设计。进行研究产物的单一皮肤应用,然后进行一次日常使用。在28天的研究期间定期评估皮肤水合,Transepidermal水分 - 损失(Tewl),皮肤生物力学性能和STRATUM Corneum(SC)的脂质含量;在产品施用之前,子集(n = 22)在产物施用之前接受了月桂基硫酸钠(SLS)攻击。所有三种润肤剂都耐受良好,并且表现出良好的性能,仅具有乐器测量的微小差异。在一次性和长时间的润肤剂持续时间延长到干燥的皮肤和干燥的SLS受损的皮肤后,皮肤水合从基线(BL)显着增加(未充气皮肤38.1-72.4%,所有三个P <0.001)。这通过皮肤弹性参数的显着增加并平行。润肤剂1和3的用法引起的SC胆固醇中的BL增加(均为9.8-12.5%,两者P <0.05)和SC游离脂肪酸水平(在末端(两者均为两者)的3.7-26.3%。学习。记录了对TEWL的持续影响。我们的调查结果支持曾经使用的所有三种润肤剂,在具有干燥皮肤的成人中。

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