首页> 外文OA文献 >Binding of Fibrin Monomer and Heparin to Thrombin in a Ternary Complex Alters the Environment of the Thrombin Catalytic Site, Reduces Affinity for Hirudin, and Inhibits Cleavage of Fibrinogen

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Binding of Fibrin Monomer and Heparin to Thrombin in a Ternary Complex Alters the Environment of the Thrombin Catalytic Site, Reduces Affinity for Hirudin, and Inhibits Cleavage of Fibrinogen

机译：纤维蛋白单体和肝素在三元复合物中凝血酶的结合改变了凝血酶催化位点的环境，降低了对血红素的亲和力，抑制纤维蛋白原的切割

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Philip J. Hogg; Craig M. Jackson; Jan K. Labanowski; Paul E. Bock;
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年度 1996
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1. By increasing the affinity of heparin for fibrin, Zn ~(2+) promotes the formation of a ternary heparin-thrombin-fibrin complex that protects thrombin from inhibition by antithrombin [J] . Chan H.H., Leslie B.A., Stafford A.R., Biochemistry . 2012,第40期

机译：通过增加肝素对血纤蛋白的亲和力，Zn〜（2+）促进三元肝素-凝血酶-血纤蛋白复合物的形成，从而保护凝血酶不受抗凝血酶的抑制
2. Thermal shift assay to probe melting of thrombin, fibrinogen, fibrin monomer, and fibrin: Gly-Pro-Arg-Pro induces a fibrin monomer-like state in fibrinogen [J] . Crossen J., Diamond S. L. Biochimica et Biophysica Acta. General Subjects . 2021,第2期

机译：热移位测定以探测凝血酶，纤维蛋白原，纤维蛋白单体和纤维蛋白的熔化：GLY-Pro-Arg-Pro在纤维蛋白原中诱导纤维蛋白单体状状态
3. Sulfated low molecular weight lignins, allosteric inhibitors of coagulation proteinases via the heparin binding site, significantly alter the active site of thrombin and factor xa compared to heparin. [J] . Brian L Henry, Umesh R Desai Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis . 2014,第5期

机译：与肝素相比，硫酸化的低分子量木质素是通过肝素结合位点的变构蛋白酶的变构抑制剂，可显着改变凝血酶和因子xa的活性位点。
4. Sulfated Low Molecular Weight Lignins Allosteric Inhibitors of Coagulation Proteinases via the Heparin Binding Site Significantly Alter the Active Site of Thrombin and Factor Xa Compared to Heparin [O] . Brian L. Henry, Umesh R. Desai -1

机译：硫酸化的低分子量木质素凝血酶通过肝素结合位点的变构抑制剂与肝素相比显着改变凝血酶和Xa因子的活性位点
5. Inhibition of heparin activity in plasma by soluble fibrin: evidence for ternary thrombin-fibrin-heparin complex formation [O] . KA Hotchkiss, CN Chesterman, PJ Hogg 1994

机译：可溶性纤维蛋白抑制血浆中肝素活性的抑制：三元凝血酶 - 纤维蛋白 - 肝素复合物形成的证据

Binding of Fibrin Monomer and Heparin to Thrombin in a Ternary Complex Alters the Environment of the Thrombin Catalytic Site, Reduces Affinity for Hirudin, and Inhibits Cleavage of Fibrinogen

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