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Tandem-Cleavage Linkers Improve the In Vivo Stability and Tolerability of Antibody-Drug Conjugates

机译：串联切割接头改善体内稳定性和抗体 - 药物缀合物的耐受性

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Stepan Chuprakov; Ayodele O. Ogunkoya; Robyn M. Barfield; Maxine Bauzon; Colin Hickle; Yun Cheol Kim; Dominick Yeo; Fangjiu Zhang; David Rabuka; Penelope M. Drake;
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1. Tandem-Cleavage Linkers Improve the In Vivo Stability and Tolerability of Antibody–Drug Conjugates [J] . Stepan Chuprakov, Ayodele O. Ogunkoya, Robyn M. Barfield, Bioconjugate Chemistry . 2021,第4期

机译：串联切割接头改善了抗体 - 药物缀合物的体内稳定性和耐受性
2. Engineered cysteine antibodies: an improved antibody-drug conjugate platform with a novel mechanism of drug-linker stability [J] . D. Sussman, L Westendorf, D. W. Meyer, Protein engineering design & selection: PEDS . 2018,第1a2期

机译：工程化半胱氨酸抗体：一种改进的抗体 - 药物共轭平台，具有新的药物接头稳定性机制
3. In Vivo Characterization of Platinum(II)-Based Linker Technology for the Development of Antibody-Drug Conjugates: Taking Advantage of Dual Labeling with Pt-195m and Zr-89 [J] . Muns Joey A., Montserrat Veronica, Houthoff Hendrik-Jan, The Journal of Nuclear Medicine . 2018,第7期

机译：铂（II）的体内表征用于抗体 - 药物缀合物的开发的基于接头技术：利用PT-195M和ZR-89的双重标记
4. Addressing Bioanalytical Challenges in Structural Characterization of Next-Generation Antibody-Drug-Conjugates Case Study: Developing a 2nd-Generation Affinity Capture LC-MS to Improve In Vivo Stability Assessment [C] . Dian Su, Carl Ng, Mehraban Khosraviani, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：解决下一代抗体 - 药物 - 缀合物的结构表征中生物分析挑战案例研究：显影第2代亲和力捕获LC-MS以改善体内稳定性评估
5. Improving Antibody-Drug Conjugate Tumor Distribution and Efficacy Using Single-Cell Imaging and Multiscale Modeling [D] . Cilliers, Cornelius 2018

机译：使用单细胞成像和多尺度建模改善抗体药物结合的肿瘤分布和功效
6. Linker Design Impacts Antibody-Drug Conjugate Pharmacokinetics and Efficacy via Modulating the Stability and Payload Release Efficiency [O] . Dian Su, Donglu Zhang 2021

机译：接头设计通过调节稳定性和有效载荷释放效率影响抗体 - 药物缀合物药代动力学和功效
7. Engineered cysteine antibodies: an improved antibody-drug conjugate platform with a novel mechanism of drug-linker stability [O] . D Sussman, L Westendorf, D W Meyer, 2018

机译：工程化半胱氨酸抗体：一种改进的抗体 - 药物共轭平台，具有新的药物接头稳定性机制

Tandem-Cleavage Linkers Improve the In Vivo Stability and Tolerability of Antibody-Drug Conjugates

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