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Phenolic Content, Antioxidant Activity, Anti-Inflammatory Potential, and Acute Toxicity Study of Thymus leptobotrys Murb. Extracts

机译:酚醛含量,抗氧化活性,抗炎潜力和胸腺叶片造成的急性毒性研究。提取物

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摘要

Thymus leptobotrys is a medicinal plant belonging to the Lamiaceae family, endemic in Morocco, and used in traditional medicine. The present work aims to study the phenolic compounds, the antioxidant activity, the anti-inflammatory effect, and the toxicity of two ethanolic and methanolic extracts of Thymus leptobotrys aerial part. The yield of the methanolic extraction (22.2%) is higher than that of the ethanolic extraction (15.8%) and is characterized by higher contents of polyphenols 243.08 mg/g GAE (mg/g of gallic acid), flavonoids 179.28 mg/g RE (mg/g of rutin), and tannins 39.31 mg/g CE (mg/g of catechin). The in vitro measurement of antioxidant activity with the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical reduction test and Trolox equivalent antioxidant capacity (TEAC) test demonstrates the higher performance of the methanolic extract. The evaluation of the anti-inflammatory effect in vivo on adult Wistar female rats leads to a very significant decrease in the inflammation of the edema compared to the standard drug (indomethacin) and the control group. The toxicity test reveals that both extracts showed no toxicity within an LD50 above 2000 mg/kg body weight of the rats.
机译:胸腺醇胨是一种属于Lamiaceae家族的药用植物,在摩洛哥的地方性,并用于传统医学。目前的作品旨在研究酚醛化合物,抗氧化活性,抗炎作用以及胸腺叶片的两种乙醇和甲醇提取物的毒性。甲醇萃取的产率(22.2%)高于乙醇萃取(15.8%)的产率,其特征在于多酚243.08mg / g gae(mg / g的小酸),黄酮醇179.28 mg / g Re (mg / g芦丁),和单宁39.31 mg / g ce(mg / g儿茶素)。抗氧化活性的体外测量与2,2-二苯基-1-富铬酰肼(DPPH)根治基试验和Trolox当量抗氧化能力(TeaC)试验表明了甲醇提取物的较高性能。与标准药物(吲哚美辛)和对照组相比,对成人Wistar雌性大鼠体内抗炎作用的评价导致水肿炎症的炎症下降。毒性测试表明,两种提取物在大鼠的2000mg / kg体重高于2000mg / kg体重的LD50内没有毒性。

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