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Dual HDAC and PI3K Inhibitor CUDC-907 Downregulates MYC and Suppresses Growth of MYC-dependent Cancers

机译：双HDAC和PI3K抑制剂CUDC-907下调MYC并抑制MICC依赖性癌症的生长

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Kaiming Sun; Ruzanna Atoyan; Mylissa A. Borek; Steven Dellarocca; Maria Elena S. Samson; Anna W. Ma; Guang-Xin Xu; Troy Patterson; David P. Tuck; Jaye L. Viner; Ali Fattaey; Jing Wang;
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1. A Pooled Analysis of Relapsed/Refractory Diffuse Large B-Cell Lymphoma Patients Treated with the Duel PI3K and HDAC Inhibitor Fimepinostat (CUDC-907), Including Patients with MYC-Altered Disease [J] . Landsburg Daniel J., Ramchandren Radhakrishnan, Lugtenburg Petronella J., Blood: The Journal of the American Society of Hematology . 2018,第NovaelaTreatmentAppr期

机译：用DUEL PI3K和HDAC抑制剂FIMEPINOSTAT（CUDC-907）治疗的复发/难治弥漫性大型B细胞淋巴瘤患者的汇总分析，包括MYC改变疾病的患者
2. Dual Inhibition of HDAC and Tyrosine Kinase Signaling Pathways with CUDC-907 Inhibits Thyroid Cancer Growth and Metastases [J] . Kotian Shweta, Zhang Lisa, Boufraqech Myriem, Clinical cancer research: an official journal of the American Association for Cancer Research . 2017,第17期

机译：用CUDC-907的HDAC和酪氨酸激酶信号传导途径的双重抑制抑制甲状腺癌生长和转移
3. The HDAC and PI3K dual inhibitor CUDC-907 synergistically enhances the antileukemic activity of venetoclax in preclinical models of acute myeloid leukemia [J] . Xinyu Li, Yongwei Su, Katie Hege, Haematologica . 2021,第5期

机译：HDAC和PI3K双重抑制剂CUDC-907协同增强威胁急性髓性白血病临床前模型的venetoclax的抗血糖活性
4. HDAC inhibitor trichostatin A suppresses osteoclastogenesis by upregulating the expression of C/EBP-β and MKP-1 [C] . Paul J. Williams, Kazi Nishu, Md Mizanur Rahman Conference on Skeletal Biology and Medicine . 2011

机译：HDAC抑制剂Trichostatin A通过上调C / EBP-β和MKP-1的表达来抑制骨细胞发生。
5. Copper Tolfenamic Acid as a Novel Survivin Inhibitor for Suppressing Pancreatic Cancer Cell Growth via Downregulating Sp1 and Sp3 Transcription Factors [D] . Hurtado, Myrna. 2018

机译：铜脱酚酸作为一种新的Survivin抑制剂，用于通过下调SP1和SP3转录因子来抑制胰腺癌细胞生长
6. Phase 1 safety and dose escalation of CUDC-907 a first-in-class oral dual inhibitor of HDAC and PI3K in relapsed or refractory lymphoma and multiple myeloma [O] . Anas Younes, Jesus G. Berdeja, Manish R. Patel, -1

机译：CUDC-907是复发难治性淋巴瘤和多发性骨髓瘤中首个口服HDAC和PI3K双重抑制剂的第一阶段安全性和剂量递增
7. Safety, tolerability, and preliminary activity of CUDC-907, a first-in-class, oral, dual inhibitor of HDAC and PI3K, in patients with relapsed or refractory lymphoma or multiple myeloma: an open-label, dose-escalation, phase 1 trial [O] . Anas Younes, Jesus G Berdeja, Manish R Patel, 2016

机译：CUDC-907的安全性，耐受性和初步活动，复发或难治性淋巴瘤或多发性骨髓瘤的患者中，HDAC和PI3K的一流，口服，双抑制剂：多种骨髓瘤：开放标签，剂量升级，阶段1审判

Dual HDAC and PI3K Inhibitor CUDC-907 Downregulates MYC and Suppresses Growth of MYC-dependent Cancers

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