Effects of Transferrin (TF) Polymorphism on the Levels of Some Blood Serum Indices in Clinically Healthy Piglets and Piglets with Diarrhoea Caused by Escherichia coli

摘要

The effect of transferrin (TF) polymorphism and the levels of some blood serum indices, functionally linked tothis protein, were studied. The following determinations were made in the blood serum of 311 hybrid sucklingpiglets - TF polymorphism, TIBC (total iron binding capacity), TF iron saturation percentage and levels of ironceruloplasmin (CP) and copper.Clinically healthy piglets and piglets with diarrhoea caused by were divided into younger (aged 10 to 14days) and older (aged 15 to 28 days). The piglets showed two genotypes, TF AB and TF BB. The TF BBgenotype dominated among clinically healthy piglets, and the TF AB genotype in those suffering from diarrhoea.TF polymorphism differentiated the levels of CP and copper in clinically healthy piglets, and modified ironconcentration and TF iron saturation percentage in piglets with diarrhoea. Regardless of health status, age hadan almost identical effect on the levels of blood serum indices in piglets of both genotypes.The differences in the levels of CP, iron, and TF iron saturation percentage in healthy piglets and piglets withdiarrhoea were modified by the presence of the TF allele, but in older piglets only.