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Antihypertensive Effects of Corn Silk Extract and Its Novel Bioactive Constituent in Spontaneously Hypertensive Rats: The Involvement of Angiotensin-Converting Enzyme Inhibition

机译:玉米丝提取物的抗高血压作用及其在自发性高血压大鼠中的新型生物活性组分:血管紧张素转化酶抑制的累积

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摘要

Corn silk tea has been used in folk medicine for anti-hypertensive healthcare. Angiotensin-converting enzyme (ACE) plays a crucial role on the homeostasis of blood pressure. However, effects of corn silk tea on ACE activity and the presence of ACE inhibitory constituents in corn silk are still unknown. Here we applied proteomics and bioinformatics approaches to identify corn silk bioactive peptides (CSBps) that target ACE from the boiling water extract of corn silk (CSE). CSE significantly reduced systolic blood pressure (SBP) levels in spontaneously hypertensive rats and inhibited the ACE activity. By proteomics coupled with bioinformatics analyses, we identified a novel ACE inhibitory peptide CSBp5 in CSE. CSBp5 significantly inhibited the ACE activity and decreased SBP levels in a dose-dependent manner. Docking analysis showed that CSBp5 occupied the substrate-binding channel of ACE and interacted with ACE via hydrogen bonds. In conclusion, we identified that CSE exhibited anti-hypertensive effects in SHRs via the inhibition of ACE, the target of most anti-hypertensive drugs. In addition, an ACE inhibitory phytopeptide CSBp5 that decreased SBP levels in rats was newly identified. Our findings supported the ethnomedical use of corn silk tea on hypertension. Moreover, the identification of ACE inhibitory phytopeptide in corn silk further strengthened our findings.
机译:玉米丝绸茶已用于民间医学中的抗高血压医疗保健。血管紧张素转换酶(ACE)对血压的稳态起着至关重要的作用。然而,玉米丝茶对ACE活动的影响以及玉米丝中ACE抑制成分的存在仍然未知。在这里,我们应用了蛋白质组学和生物信息学方法来鉴定玉米丝生物活性肽(CSBP),该玉米丝绸生物活性肽(CSBPS)从玉米丝(CSE)的沸水提取物中靶向ACE。 CSE显着降低了自发性高血压大鼠的收缩压(SBP)水平,并抑制了ACE活动。通过蛋白质组学与生物信息学分析,我们在CSE中鉴定了一种新型ACE抑制肽CSBP5。 CSBP5以剂量依赖的方式显着抑制ACE活性并降低了SBP水平。对接分析表明,CSBP5占据ACE的基材结合通道并通过氢键与ACE相互作用。总之,我们发现CSE通过抑制ACE,大多数抗高血压药物的靶向抗高血压作用。此外,新鉴定了一种ACE抑制植物植物CSBP5,降低大鼠SBP水平的CSBP5。我们的调查结果支持玉米丝茶的血液用途对高血压。此外,玉米丝中ACE抑制植物肽的鉴定进一步加强了我们的研究结果。

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