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The inhibitory receptor CD94/NKG2A on CD8+ tumor-infiltrating lymphocytes in colorectal cancer: a promising new druggable immune checkpoint in the context of HLAE/β2m overexpression

机译：CD8 +肿瘤浸润淋巴细胞的抑制受体CD94 / NKG2A在结肠直肠癌中：HLAE /β2M过表达的背景下具有新的可用性免疫检查点

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Juliette Eugène; Nicolas Jouand; Kathleen Ducoin; Delphine Dansette; Romain Oger; Cécile Deleine; Edouard Leveque; Guillaume Meurette; Juliette Podevin; Tamara Matysiak; Jaafar Bennouna; Stéphane Bezieau; Christelle Volteau; Wassila El Alami Thomas; Jerôme Chetritt; Olivier Kerdraon; Pierre Fourquier; Emilie Thibaudeau; Frédéric Dumont; Jean-François Mosnier; Claire Toquet; Anne Jarry; Nadine Gervois; Céline Bossard;
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1. Expression of the inhibitory receptor CD94/NKG2A on CD8+tumour-infiltrating lymphocytes in colorectal cancer: a new promising druggable immune checkpoint in a context of HLA-E/b2microglobuline overexpression by tumour cells [J] . Bossard C., Eugene J., Jouand N., Virchows Archiv: an international journal of pathology . 2019,第Suppla1期

机译：抑制剂受体CD94 / NKG2A对结直肠癌CD8 +肿瘤浸润淋巴细胞的表达：肿瘤细胞HLA-E / B2MICROGLOBLOBLINE过表达的背景下的新有毒性免疫检查点
2. Prostaglandin E2 induces the expression of functional inhibitory CD94/NKG2A receptors in human CD8+ T lymphocytes by a cAMP-dependent protein kinase A type I pathway. [J] . Zeddou M, Greimers R, de Valensart N, Biochemical Pharmacology . 2005,第5期

机译：前列腺素E2通过cAMP依赖性蛋白激酶A型I途径诱导人CD8 + T淋巴细胞中功能性抑制性CD94 / NKG2A受体的表达。
3. Downregulation of CD94/NKG2A inhibitory receptors on CD8+ T cells in HIV infection is more pronounced in subjects with detected viral load than in their aviraemic counterparts [J] . Mustapha Zeddou, Souad Rahmouni, Arnaud Vandamme, Retrovirology . 2007,第S1期

机译：在检测到病毒载量的受试者中，在HIV感染中，CD8 + T细胞上的CD94 / NKG2A抑制受体的下调更为明显，而在无病毒的受试者中
4. HLA class I-specific inhibitory receptors in human T lymphocytes: Interleukin 15-induced expression of CD94/NKG2A in superantigen- or alloantigen-activated CD8+ T cells [O] . Maria Cristina Mingari, Marco Ponte, Stefania Bertone, 1998

机译：人类T淋巴细胞中HLA I类特异性抑制受体：白细胞介素15诱导超抗原或同种抗原激活的CD8 + T细胞中CD94 / NKG2A的表达
5. Up-regulation of Inhibitory Natural Killer Receptors CD94/NKG2A with Suppressed Intracellular Perforin Expression of Tumor-Infiltrating CD8+ T Lymphocytes in Human Cervical Carcinoma [O] . Bor-Ching Sheu, Shin-Heng Chiou, Ho-Hsiung Lin, 2005

机译：抑制自然杀伤受体的上调CD94 / NKG2A，抑制肿瘤浸润CD8 + T淋巴细胞的细胞内穿孔蛋白表达人颈癌

The inhibitory receptor CD94/NKG2A on CD8+ tumor-infiltrating lymphocytes in colorectal cancer: a promising new druggable immune checkpoint in the context of HLAE/β2m overexpression

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