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Impact of acupuncture for allergic rhinitis on the activity of the hypothalamus-pituitary-adrenal axis: study protocol for a randomized controlled trial

机译:针刺对丘脑 - 垂体肾上腺轴活性的影响:随机对照试验的研究方案

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Abstract Background Patients with moderate and severe persistent allergic rhinitis (AR) have long-term physical and mental stress, leading to dysfunction of the hypothalamus-pituitary-adrenal (HPA) axis, which results in recurrence of AR. Previous research has proved acupuncture can regulate the function of the neuron-endocrine-immune system and contribute to improving the quality of life of patients with AR. This research aims to investigate the mechanism of acupuncture on the HPA axis in patients with moderate or severe persistent AR. Methods/design This randomized controlled trial aims to study the impact of acupuncture on the HPA axis of patients with moderate and severe AR. This research also aims to compare the curative effects of different treatments in three groups of patients: those receiving western medicine, western medicine and conventional acupuncture, or western medicine and mind-regulating acupuncture. We will study the therapeutic effect of acupuncture and the correlation between the changes of therapeutic indexes and experimental indexes after the treatments. Therapeutic indexes include the Visual Analog Scale (VAS) of nasal symptoms and the Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) for AR patients; experimental indexes include corticotropin releasing hormone (CRH), adreno-corticotropic hormone (ACTH), cortisol (CORT), interleukin 4 (IL-4), and interferon-γ (IFN-γ). Discussion The results of this trial will provide evidence for the influence of chronic, long-term, repeated stimulation in patients with moderate and severe persistent AR and the impact of acupuncture on the HPA axis of these patients. Trial registration Acupuncture-Moxibustion Clinical Trial Registry, AMCTR-IOR-16000009. Registered on 22 August 2016.
机译:摘要背景患有中度和重度持续性过敏性鼻炎(AR)具有长期的身体和精神压力,导致下丘脑 - 垂体 - 肾上腺轴(HPA),这导致AR复发的功能障碍。以前的研究已经证明针灸可调节神经 - 内分泌 - 免疫系统的功能,并有助于改善患者的AR的生活质量。本研究旨在探讨针刺对HPA轴在患者的机制中度或重度持续性AR。方法/设计这个随机对照试验目的是研究针灸对患者的HPA轴的影响,中度和重度AR。这项研究还旨在比较三组患者的不同治疗方法的疗效:那些接受西医,西药和传统的针灸,或西药和精神调节针灸。我们将研究针灸的治疗效果和治疗指数的治疗后的变化与实验指标之间的相关性。治疗性指标包括鼻部症状的视觉模拟评分(VAS)和生活调查问卷的质量结膜炎(RQLQ)为AR的患者;实验索引包括促肾上腺皮质激素释放激素(CRH),促肾上腺促肾上腺皮质激素(ACTH),皮质醇(CORT),白细胞介素4(IL-4),和干扰素γ(IFN-γ)。讨论这项试验的结果将提供慢性,长期的影响的证据,在患者的中度和重度持续性AR和针灸对这些患者的HPA轴的影响反复刺激。试验注册针灸临床试验注册,AMCTR-10R-16000009。注册2016年8月22日。

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