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Crystal Structure of the T877A Human Androgen Receptor Ligand-binding Domain Complexed to Cyproterone Acetate Provides Insight for Ligand-induced Conformational Changes and Structure-based Drug Design

机译：T877A人雄激素受体配体结合域络合到硫代丙烯酸酯的T877A人雄激素受体配体结合结构域提供了对配体诱导的构象变化和基于结构的药物设计的洞察力

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Casey E. Bohl; Zengru Wu; Duane D. Miller; Charles E. Bell; James T. Dalton;
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年度 2007
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1. Comparison of crystal structures of human androgen receptor ligand-binding domain complexed with various agonists reveals molecular determinants responsible for binding affinity. [J] . Pereira de Jesus Tran K, Cote PL, Cantin L, Protein Science: A Publication of the Protein Society . 2006,第5期

机译：人雄激素受体配体结合域与各种激动剂复合的晶体结构的比较揭示了负责结合亲和力的分子决定簇。
2. Study of the impact of the T877A mutation on ligand-induced helix-12 positioning of the androgen receptor resulted in design and synthesis of novel antiandrogens. [J] . Zhou J, Liu B, Geng Proteins: Structure, Function, and Genetics . 2010,第3期

机译：T877A突变对配体诱导的雄激素受体的helix-12定位的影响的研究导致了新型抗雄激素的设计和合成。
3. Dynamic communication between androgen and coactivator: mutually induced conformational perturbations in androgen receptor ligand-binding domain. [J] . Xu X, Yang W, Wang X, Proteins: Structure, Function, and Genetics . 2011,第4期

机译：雄激素和共激活剂之间的动态交流：雄激素受体配体结合域中相互诱导的构象扰动。
4. A novel conformation optimization model and algorithm for structure-based drug design [C] . Ling Kang, Honglin Li, Xiaoyu Zhao, ICMSI;International conference of molecular simulations and applied informatics technologies . 2010

机译：基于结构的药物设计的新型构象优化模型和算法
5. Crystal structure of the human estrogen receptor alpha ligand-binding domain: Estradiol complex [D] . Tanenbaum, David Michael. 1998

机译：人雌激素受体α配体结合域的晶体结构：雌二醇复合物
6. Crystal Structure of the T877A Human Androgen Receptor Ligand-binding Domain Complexed to Cyproterone Acetate Provides Insight for Ligand-induced Conformational Changes and Structure-based Drug Design [O] . Casey E. Bohl, Zengru Wu, Duane D. Miller, -1

机译：T877A人类雄激素受体配体结合域的晶体结构与醋酸环丙孕酮复合提供了配体诱导的构象变化和基于结构的药物设计的见解。
7. Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone [O] . Sack, John S., Kish, Kevin F., Wang, Chihuei, 2001

机译：的配体结合域的晶体结构雄激素受体及其T877A突变体与天然激动剂二氢睾丸激素

Crystal Structure of the T877A Human Androgen Receptor Ligand-binding Domain Complexed to Cyproterone Acetate Provides Insight for Ligand-induced Conformational Changes and Structure-based Drug Design

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