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Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein–Protein Interaction between Menin and Mixed Lineage Leukemia (MLL)

机译：物业焦点结构的小分子抑制剂的优化蛋白质 - 蛋白质 - 混合谱系白血病（MLL）

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Dmitry Borkin; Jonathan Pollock; Katarzyna Kempinska; Trupta Purohit; Xiaoqin Li; Bo Wen; Ting Zhao; Hongzhi Miao; Shirish Shukla; Miao He; Duxin Sun; Tomasz Cierpicki; Jolanta Grembecka;
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1. Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL) [J] . Borkin Dmitry, Pollock Jonathan, Kempinska Katarzyna, Journal of Medicinal Chemistry . 2016,第3期

机译：基于特性的结构优化的小分子抑制剂的蛋白和蛋白之间的相互作用的混合蛋白谱系白血病（MLL）的小分子抑制剂的优化。
2. Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction [J] . Aguilar Angelo, Zheng Ke, Xu Tianfeng, Journal of Medicinal Chemistry . 2019,第13期

机译：基于结构的M-89发现作为Menin-Mex-Mexeage白血病（Menin-MLL）蛋白质 - 蛋白质相互作用的高效抑制剂
3. High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein?Protein Interaction [J] . Shihan He, Timothy J. Senter, Jonathan Pollock, Journal of Medicinal Chemistry . 2014,第4期

机译：Menin混合谱系白血病（MLL）相互作用的高亲和力小分子抑制剂紧密模仿天然蛋白-蛋白质相互作用。
4. Overexpression of protein disulfide isomerase-like protein in a mouse leukemia L1210 cell lineselected for resistance to 4-methyl-5-amino-l-formylisoquinoline thiosemicarbazone, aribonucleotide reductase inhibitor [C] . Taria R. Crenshaw, Joseph G. Cory International Symposium on Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues . 2003

机译：在小鼠白血病L1210细胞中过表达蛋白二硫化物异构酶样蛋白，其含有对抗4-甲基-5-氨基-1-甲醛异喹啉硫代喹啉硫代喹啉硫代喹啉的，因此
5. A General and Stereoselective Approach for the Construction of Azabicyclic Compounds: Applications to the Synthesis of (+)-Amabiline and Grandisine D; Structure-based Design of Small Molecule Inhibitors of the Menin-MLL Protein-protein Interaction. [D] . Senter, Timothy J. 2015

机译：构造氮杂双环化合物的一般和立体选择方法：在合成（+）-氨苄青霉素和Grandisine D中的应用； Menin-MLL蛋白-蛋白相互作用的小分子抑制剂的基于结构的设计。
6. Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein–Protein Interaction between Menin and Mixed Lineage Leukemia (MLL) [O] . Dmitry Borkin, Jonathan Pollock, Katarzyna Kempinska, -1

机译：基于属性的基于结构的小分子抑制剂对Menin和混合谱系白血病（MLL）之间蛋白质-蛋白质相互作用的优化
7. Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the ProteinProtein Interaction between Menin and Mixed Lineage Leukemia (MLL) [O] . -1

机译：属性聚焦结构的小分子抑制剂的优化，蛋白质和混合谱系白血病之间的蛋白质蛋白质相互作用（MLL）

Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein–Protein Interaction between Menin and Mixed Lineage Leukemia (MLL)

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