首页> 外文OA文献 >Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation

【2h】

Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation

机译：N-（5-氟吡啶-2-基）-6-甲基-4-（嘧蛋白-5-基氧基）吡啶胺的发现（Vu0424238）：选择临床评价的代谢谷氨酸受体亚型5的新型阴性变形调节剂

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

著录项
引文网络
相似文献
相关主题

著录项

作者
Andrew S. Felts; Alice L. Rodriguez; Anna L. Blobaum; Ryan D. Morrison; Brittney S. Bates; Analisa Thompson Gray; Jerri M. Rook; Mohammed N. Tantawy; Frank W. Byers; Sichen Chang; Daryl F. Venable; Vincent B. Luscombe; Gilles D. Tamagnan; Colleen M. Niswender; J. Scott Daniels; Carrie K. Jones; P. Jeffrey Conn; Craig W. Lindsley; Kyle A. Emmitte;
展开▼
作者单位

展开▼
年度 2017
总页数
原文格式 PDF
正文语种
中图分类

相似文献

外文文献
中文文献
专利

1. Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation [J] . Felts Andrew S., Rodriguez Alice L., Blobaum Anna L., Journal of Medicinal Chemistry . 2017,第12期

机译：N-（5-氟吡啶-2-基）-6-甲基-4-（嘧蛋白-5-基氧基）吡啶胺的发现（Vu0424238）：选择临床评价的代谢谷氨酸受体亚型5的新型阴性变形调节剂
2. Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents [J] . Engers Julie L., Rodriguez Alice L., Konkol Leah C., Journal of Medicinal Chemistry . 2015,第18期

机译：发现具有抗抑郁和抗焦虑活性的啮齿类动物代谢型谷氨酸受体亚型3选择性和中枢神经系统渗透性负变构调节剂。
3. Discovery of Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 5 from a Series of N-(1,3-Diphenyl-1H- pyrazol-5-yl)benzamides That Potentiate Receptor Function in Vivo. [J] . Lindsley CW, Wisnoski DD, Leister WH, Journal of Medicinal Chemistry . 2004,第24期

机译：从一系列增强体内受体功能的N-（1,3-二苯基-1H-吡唑-5-基）苯甲酰胺中发现代谢型谷氨酸受体亚型5的正变构调节剂。
4. IDENTIFICATION OF NADPH-INDEPENDENT GSH CONJUGATES OF ACETYLENE-CONTAINING POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR SUBTYPE 5 [C] . Xiaoliang Zhuo, Xiaohua Huang, Andrew Degnan, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：鉴定含乙炔谷氨酸受体亚型5的含乙炔的阳性变构调节剂的NADPH-无关的GSH缀合物
5. Discovery and Characterization of Selective Negative Allosteric Modulators of Human alpha4beta2 Neuronal Nicotinic Receptors. [D] . Henderson, Brandon J. 2011

机译：发现和表征人类alpha4beta2神经元烟碱受体的选择性负变构调节剂。
6. Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide(VU0424238): A Novel Negative Allosteric Modulator of MetabotropicGlutamate Receptor Subtype 5 Selected for Clinical Evaluation [O] . AndrewS. Felts, Alice L. Rodriguez, Anna L. Blobaum, -1

机译：N-（5-氟吡啶-2-基）-6-甲基-4-（嘧啶-5-基氧基）吡啶啉的发现（VU0424238）：新型的代谢型负变构调节剂选择谷氨酸受体亚型5进行临床评估
7. Discovery of Positive Allosteric Modulators for the Metabotropic Glutamate Receptor Subtype 5 from a Series of N-(1, 3-Diphenyl-1H-pyrazol-5-yl) benzamides That Potentiate Receptor Function in Vivo [O] . -1

机译：从一系列N-（1,3-二苯基-1H-吡唑-5-吡唑-5-基）苯甲酰胺中的代谢谷氨酸受体亚型5的阳性变构调节剂的发现，该苯甲酰胺在体内具有增强的受体功能

Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation

著录项

引文网络

相似文献

相关主题

期刊订阅