Structure-Activity Relationships of a Novel Group of Large-Conductance Ca2+-Activated K+(BK) Channel Modulators: The GoSlo-SR Family

摘要

Opening up ion channels: We synthesised a series of anthraquinone analogues, called the GoSlo-SR family. Their effects on bladder smooth muscle BK channels were examined and, as shown, shifted voltage dependent activation >-100 mV (at 10 μM). They were more efficacious than NS11021 and could provide a new scaffold for the design of efficacious BK openers.