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Metabotropic Glutamate Receptor 5 Activation Enhances Tyrosine Phosphorylation of the N-methyl-D-aspartate (NMDA) Receptor and NMDA-Induced Cell Death in Hippocampal Cultured Neurons

机译：代谢谷氨酸受体5活化可增强酪氨酸磷酸化 - 甲基 - <小> D - 海岸酸盐（NMDA）受体和NMDA诱导的细胞死亡中的海马培养神经元

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Norio Takagi; Shintaro Besshoh; Tetsuro Marunouchi; Satoshi Takeo; Kouichi Tanonaka;
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年度 2012
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1. Metabotropic glutamate receptor 5 activation enhances tyrosine phosphorylation of the N-methyl-D-aspartate (NMDA) receptor and NMDA-induced cell death in hippocampal cultured neurons [J] . Takagi N., Besshoh S., Marunouchi T., Biological & pharmaceutical bulletin . 2012,第12期

机译：代谢型谷氨酸受体5激活增强了海马培养的神经元中N-甲基-D-天冬氨酸（NMDA）受体的酪氨酸磷酸化和NMDA诱导的细胞死亡
2. Both N-methyl-D-aspartate (NMDA) and non-NMDA receptors mediate glutamate-induced cleavage of the cyclin-dependent kinase 5 (cdk5) activator p35 in cultured rat hippocampal neurons. [J] . Kerokoski P, Suuronen T, Salminen A, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2004,第2期

机译：N-甲基-D-天门冬氨酸（NMDA）和非NMDA受体均介导谷氨酸诱导的大鼠海马神经元细胞周期蛋白依赖性激酶5（cdk5）激活剂p35的裂解。
3. Effects of metabotropic glutamate mGlu5 receptor antagonist on tyrosine phosphorylation of NMDA receptor subunits and cell death in the hippocampus after brain ischemia in rats [J] . TakagiN., BesshohS., MarunouchiT., Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2012,第1期

机译：代谢型谷氨酸mGlu5受体拮抗剂对大鼠脑缺血后海马NMDA受体亚基酪氨酸磷酸化的影响
4. Single Neuron Imaging Reveals Metabotropic Glutamate Receptor-Mediated Bursting and Delay in Calcium Oscillation in Hippocampal Neurons [C] . Ranjana Singh, Abha Saxena, Lopamudra Giri Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2019

机译：单神经元成像显示海马神经元代谢型谷氨酸受体介导的爆发和钙振荡的延迟。
5. Excitatory effect of group I metabotropic glutamate receptor activation on cultured rat retinal ganglion cells. [D] . Yu, Jianing. 2006

机译：I组代谢型谷氨酸受体激活对培养的大鼠视网膜神经节细胞的兴奋作用。
6. Metabotropic Glutamate Receptors and Dopamine Receptors Cooperate to Enhance Extracellular Signal-Regulated Kinase Phosphorylation in Striatal Neurons [O] . Pamela J. Voulalas, Lynne Holtzclaw, Jennifer Wolstenholme, 2005

机译：代谢型谷氨酸受体和多巴胺受体协同增强纹状体神经元中细胞外信号调节的激酶磷酸化。
7. Metabotropic glutamate receptor 3 neuroprotection A. Berent-Spillson and J. W. Russell Received June 12, 2006; revised manuscript received October 3, 2006; accepted October 5, 2006. Address correspondence and reprint requests to James W. Russell, Department of Neurology, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201-1595, USA. E-mail: jruss@umich.edu Abbreviations used : APDC , 2 R ,4 R -4-aminopyrrolidine-2,4-dicarboxylate (specific metabotropic glutamate receptor 3 agonist) ; BSO , buthionine sulfoximine (GSH synthesis inhibitor) ; caspase , cysteine-requiring aspartate protease ; CysGly , cysteinylglycine (GSH degradation product) ; DAPI , 4′-6-diamidino-2-phenylindole ; DCF , dichlorodihydrofluorescein ; DCFDA , 5-(and 6)-chloromethyl-2′,7′-dichlorodihydrofluorescein diacetate, acetyl ester ; DHE , dihydroethidium ; DRG , dorsal root ganglion ; FCCP , carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone (electron transport uncoupler) ; GCP II/III , glutamate carboxypeptidase II/III ; GSH , glutathione ; GSH-EE , glutathione ethyl ester ; GST , glutathione-s-transferase ; H 2 O 2 , hydrogen peroxide ; HBSS , Hank’s balanced salt solution ; JC-1 , 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolylcarbocyanine iodide ; MCB , monochlorobimane ; mGluR , metabotropic glutamate receptor ; NAAG , N -acetyl-aspartyl-glutamate ; PBS , phosphate-buffered saline ; PCD , programmed cell death ; Rh123 , rhodamine123 ; ROS , reactive oxygen species ; δψ μ , inner mitochondrial membrane potential . Metabotropic glutamate receptor 3 protects neurons from glucose-induced oxidative injury by increasing intracellular glutathione concentration [O] . Berent-Spillson Alison, Russell James W. 2007

机译：代谢型谷氨酸受体3神经保护a. Berent-spillson和J. W. Russell于2006年6月12日收到;修订稿于2006年10月3日收到; 2006年10月5日接受。美国马里兰州巴尔的摩市南格林街22号，马里兰大学医学院神经病学系James W. Russell的地址通信和重印申请。电子邮件：jruss@umich.edu使用的缩写：apDC，2R，4R-4-氨基吡咯烷-2,4-二羧酸酯（特异性代谢型谷氨酸受体3激动剂）; BsO，丁硫氨酸亚砜亚胺（GsH合成抑制剂）;半胱天冬酶，半胱氨酸需要的天冬氨酸蛋白酶; CysGly，半胱氨酰甘氨酸（GsH降解产物）; DapI，4'-6-二脒基-2-苯基吲哚; DCF，二氯二氢荧光素; DCFDa，5-（和6） - 氯甲基-2'，7'-二氯二氢荧光素二乙酸酯，乙酰酯; DHE，二氢乙锭; DRG，背根神经节; FCCp，羰基氰化物4-（三氟甲氧基）苯腙（电子传输解偶联剂）; GCp II / III，谷氨酸羧肽酶II / III;谷胱甘肽;谷胱甘肽; GsH-EE，谷胱甘肽乙酯; GsT，谷胱甘肽-s-转移酶; H 2 O 2，过氧化氢; HBss，Hank的平衡盐溶液; JC-1,5,5'，6,6'-四氯-1,1'，3,3'-四乙基苯并咪唑基酞菁碘化物; mCB，monochlorobimane; mGluR，代谢型谷氨酸受体; NaaG，N-乙酰基 - 天冬氨酰谷氨酸; pBs，磷酸盐缓冲盐水; pCD，程序性细胞死亡; Rh123，罗丹明123;活性氧，活性氧; δψμ，线粒体内膜电位。代谢型谷氨酸受体3通过增加细胞内谷胱甘肽浓度来保护神经元免受葡萄糖诱导的氧化损伤

Metabotropic Glutamate Receptor 5 Activation Enhances Tyrosine Phosphorylation of the N-methyl-D-aspartate (NMDA) Receptor and NMDA-Induced Cell Death in Hippocampal Cultured Neurons

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