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Compensatory Insulin Receptor (IR) Activation on Inhibition of Insulin-Like Growth Factor-1 Receptor (IGF-1R): Rationale for Cotargeting IGF-1R and IR in Cancer

机译：补偿胰岛素受体（IR）抑制胰岛素样生长因子-1受体的抑制（IGF-1R）：用于Cotargeting IGF-1R和IR癌症的基本原理

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Elizabeth Buck; Prafulla C. Gokhale; Susan Koujak; Eric Brown; Alexandra Eyzaguirre; Nianjun Tao; Maryland Rosenfeld-Franklin; Lorena Lerner; M. Isabel Chiu; Robert Wild; David Epstein; Jonathan A. Pachter; Mark R. Miglarese;
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1. Compensatory insulin receptor (IR) activation on inhibition of insulin-like growth factor-1 receptor (IGF-1R): rationale for cotargeting IGF-1R and IR in cancer. [J] . Buck E, Gokhale PC, Koujak S, Molecular cancer therapeutics . 2010,第10期

机译：抑制胰岛素样生长因子1受体（IGF-1R）的补偿性胰岛素受体（IR）活化：在癌症中共同靶向IGF-1R和IR的原理。
2. Insulin-like growth factor-1 receptor inhibition induces a resistance mechanism via the epidermal growth factor receptor/HER3/AKT signaling pathway: rational basis for cotargeting insulin-like growth factor-1 receptor and epidermal growth factor receptor in hepatocellular carcinoma. [J] . Desbois Mouthon C, Baron A, Blivet Van Eggelpoel MJ Clinical cancer research: an official journal of the American Association for Cancer Research . 2009,第17期

机译：胰岛素样生长因子-1受体抑制通过表皮生长因子受体/ HER3 / AKT信号传导途径诱导耐药机制：在肝细胞癌中共同靶向胰岛素样生长因子-1受体和表皮生长因子受体的合理依据。
3. Functional collaboration of insulin-like growth factor-1 receptor (IGF-1R), but not insulin receptor (IR), with acute GH signaling in mouse calvarial cells [J] . GanY., PatersonA.J., ZhangY., Endocrinology . 2014,第3期

机译：胰岛素样生长因子-1受体（IGF-1R）而非胰岛素受体（IR）在小鼠颅盖细胞中与急性GH信号传导的功能协作
4. Discovery and SAR of Thiazolidine-2,4-dione Analogues as Insulin-like Growth Factor-1 Receptor (IGF-1R) Inhibitors via Hierarchical Virtual Screening [C] . Xiaofeng Liu, Hua Xie, Cheng Luo, ICMSI;International conference of molecular simulations and applied informatics technologies . 2010

机译：噻唑烷-2,4-二酮类似物作为胰岛素样生长因子-1受体（IGF-1R）抑制剂的发现和SAR通过分层虚拟筛选
5. Suppressor of cytokine signaling-2 (SOCS2) and epidermal growth factor (EGF) modulate insulin-like growth factor-I receptor (IGF-IR) signaling in intestinal cancer. [D] . Newton, Victoria A. 2010

机译：细胞因子信号传导抑制因子2（SOCS2）和表皮生长因子（EGF）的抑制因子调节肠癌中胰岛素样生长因子-I受体（IGF-IR）的信号传导。
6. Functional Collaboration of Insulin-Like Growth Factor-1 Receptor (IGF-1R) but Not Insulin Receptor (IR) With Acute GH Signaling in Mouse Calvarial Cells [O] . Yujun Gan, Andrew J. Paterson, Yue Zhang, -1

机译：胰岛素类似生长因子-1受体（IGF-1R）而非胰岛素受体（IR）的功能协作在小鼠颅盖细胞中具有急性GH信号传导
7. Insulin-Like Growth Factor-1 Receptor Inhibition Induces a Resistance Mechanism via the Epidermal Growth Factor Receptor/HER3/AKT Signaling Pathway: Rational Basis for Cotargeting Insulin-Like Growth Factor-1 Receptor and Epidermal Growth Factor Receptor in Hepatocellular Carcinoma [O] . Christèle Desbois-Mouthon, Aurore Baron, Marie-José Blivet-Van Eggelpoël, 2009

机译：胰岛素样生长因子-1受体抑制诱导通过表皮生长因子受体/ HER3 / AKT信号通路的抗性机制：在肝细胞癌中的Cotarging胰岛素样生长因子-1受体和表皮生长因子受体的合理基础

Compensatory Insulin Receptor (IR) Activation on Inhibition of Insulin-Like Growth Factor-1 Receptor (IGF-1R): Rationale for Cotargeting IGF-1R and IR in Cancer

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