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Pyrazolylthiazole as ΔF508-Cystic Fibrosis Transmembrane Conductance Regulator Correctors with Improved Hydrophilicity Compared to Bithiazoles

机译：吡唑龙作为ΔF508-囊性纤维化跨膜电导调节器校正器，其与Bithiazoles相比改善了亲水性

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Long Ye; John M. Knapp; Panjamaporn Sangwung; James C. Fettinger; A. S. Verkman; Mark J. Kurth;
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年度 2010
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1. Pyrazolylthiazole as Δf508-cystic fibrosis transmembrane conductance regulator correctors with improved hydrophilicity compared to bithiazoles [J] . Ye L., Knapp J.M., Sangwung P., Journal of Medicinal Chemistry . 2010,第9期

机译：吡唑基噻唑作为Δf508-囊性纤维化跨膜电导调节剂校正剂，比噻唑类具有更高的亲水性
2. Potent s-cis-locked bithiazole correctors of DeltaF508 cystic fibrosis transmembrane conductance regulator cellular processing for cystic fibrosis therapy. [J] . Yu GJ, Yoo CL, Yang BX, Journal of Medicinal Chemistry . 2008,第19期

机译：强大的s-顺式联苯噻唑校正剂，用于DeltaF508囊性纤维化跨膜电导调节剂细胞处理，用于囊性纤维化治疗。
3. Novel Hits in the Correction of Delta F508-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Protein: Synthesis, Pharmacological, and ADME Evaluation of Tetrahydropyrido[4,3-d]pyrimidines for the Potential Treatment of Cystic Fibrosis [J] . Pesci Elisabetta, Bettinetti Laura, Fanti Paola, Journal of Medicinal Chemistry . 2015,第24期

机译：校正ΔF508-囊性纤维化跨膜电导调节剂（CFTR）蛋白的新命中：四氢吡啶并[4,3-d]嘧啶的合成，药理学和ADME评价用于潜在的囊性纤维化治疗
4. Cystic fibrosis transmembrane conductance regulator gene mutations cause 'black' pigment gallstone formation: new insights from mouse models and implications for therapeutic interventions in cystic fibrosis [C] . A. L. BRODERICK, H. WITTENBURG, M. A. LYONS, Falk Symposium . 2004

机译：囊性纤维化跨膜电导调节剂基因突变引起'黑色'颜料胆结石形成：来自小鼠模型的新见解，以及对囊性纤维化治疗干预的影响
5. Cystic Fibrosis Transmembrane Conductance Regulator Modulator Therapies in Cystic Fibrosis: A Retrospective Evaluation of a Nationwide Specialty Pharmacy Database [D] . Mehta, Zumi . 2020

机译：囊性纤维化跨膜电导调节剂调节剂患者囊性纤维化：全国特色药房数据库的回顾性评估
6. Pyrazolylthiazole as ΔF508-Cystic Fibrosis Transmemberane Conductance Regulator Correctors with Improved Hydrophilicity Compared to Bithiazoles [O] . Long Ye, John M. Knapp, Panjamaporn Sangwung, -1

机译：pyrazolylthiazole为ΔF508-囊性纤维化Transmemberane传导调节与改善亲水性校正器相比Bithiazoles
7. 5’-adenosine monophosphate mediated cooling treatment enhances ΔF508-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) stability [O] . 2015

机译：5’-腺苷一磷酸介导的冷却处理增强了ΔF508-囊性纤维化跨膜电导调节器（CFTR）的稳定性

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