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Ceramide synthase inhibitor fumonisin B1 inhibits apoptotic cell death in SCC17B human head and neck squamous carcinoma cells after Pc4 photosensitization

机译：在PC4光敏之后，神经酰胺合酶抑制剂Fumonisin B1抑制SCC17B人体头部和颈部鳞状癌细胞中的凋亡细胞死亡

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Nithin B. Boppana; Mohamed Kodiha; Ursula Stochaj; Ho-sheng Lin; Adriana Haimovitz-Friedman; Alicja Bielawska; Jacek Bielawski; George W. Divine; John A. Boyd; Mladen Korbelik; Duska Separovic;
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1. Ceramide synthase inhibitor fumonisin Bl inhibits apoptotic cell death in SCC17B human head and neck squamous carcinoma cells after Pc4 photosensitization [J] . Nithin B. Boppana, Mohamed Kodiha, Ursula Stochaj Photochemical & photobiological sciences: the official journal of the European Photochemistry Association and the European Society for Photobiology . 2014,第11期

机译：神经酰胺合酶抑制剂伏马毒素B1抑制Pc4光敏后SCC17B人头颈部鳞状细胞凋亡
2. spase activation and the inhibition of Bfl-1 expression, all of which were blocked by the antioxidant, N-acetyl-L-cysteine (NAC). Moreover, addition of ceramide rescued the NAC-inhibited MAPK activation and pretreatment with the ceramide synthase inhibitor, fumonisin B1, reduced cell death. CONCLUSION: Our results suggest that in DU-145 prostate cancer cells: (i) EGCG+ibuprofen treatment has a synergistic effect on apoptosis, and (ii) oxidative stress, directly or indirectly via ceramide synthes [J] . The Netherlands journal of medicine. . 2009,第6期

机译：蛋白酶激活和Bfl-1表达的抑制，所有这些都被抗氧化剂N-乙酰基-L-半胱氨酸（NAC）阻断。此外，添加神经酰胺可挽救NAC抑制的MAPK活化，并用神经酰胺合酶抑制剂伏马菌素B1预处理可减少细胞死亡。结论：我们的结果表明，在DU-145前列腺癌细胞中：（i）EGCG +布洛芬治疗对细胞凋亡具有协同作用，并且（ii）通过神经酰胺合成直接或间接地产生氧化应激。
3. C6-pyridinium ceramide sensitizes SCC17B human head and neck squamous cell carcinoma cells to photodynamic therapy [J] . Boppana Nithin B., Stochaj Ursula, Kodiha Mohamed, Journal of Photochemistry and Photobiology, B. Biology: Official Journal of the European Society for Photobiology . 2015,第Null期

机译：C6-吡啶神经酰胺可使SCC17B人头颈部鳞状细胞癌细胞对光动力疗法敏感
4. Discovery of novel small molecules that inhibit Human tongue squamous carcinoma cells (Tca8113) [C] . Yakun Ge, Shanshan LI, Weirong SHANG, International symposium on pharmacogenomics and the regulation of drug metabolism enzymes and genes. . 2010

机译：发现抑制人舌鳞状癌细胞（Tca8113）的新型小分子
5. GGTI-298 in combination with EGFR inhibitors: Evaluating a novel therapy in head and neck squamous cell carcinomas. [D] . Zahr, Stephanie. 2013

机译：GGTI-298与EGFR抑制剂联合使用：评价头颈部鳞状细胞癌的新疗法。
6. Ceramide synthase inhibitor fumonisin B1 inhibits apoptotic cell death in SCC17B human head and neck squamous carcinoma cells after Pc4 photosensitization [O] . Nithin B. Boppana, Mohamed Kodiha, Ursula Stochaj, -1

机译：神经酰胺合酶抑制剂伏马菌素B1抑制Pc4光敏作用后SCC17B人头颈部鳞状细胞癌细胞的凋亡
7. Inhibition of transcription factor nuclear factor-κB by a mutant inhibitor-κBα attenuates resistance of human head and neck squamous cell carcinoma to TNF-α caspase-mediated cell death [O] . D C Duffey, C V Crowl-Bancroft, Z Chen, 2000

机译：通过突变抑制剂-κBα对转录因子核因子-κB的抑制抑制人头和颈部鳞状细胞癌对TNF-α胱天蛋白介导的细胞死亡的抗性

Ceramide synthase inhibitor fumonisin B1 inhibits apoptotic cell death in SCC17B human head and neck squamous carcinoma cells after Pc4 photosensitization

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