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542. Novel Barcode-Based In Vivo Screening Method for Generating De Novo AAV Serotypes for CNS-Directed Gene Therapy

机译：542.基于小型条形码的基于体内筛选方法，用于生成DE Novo AAV血清型用于CNS针对基因治疗

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Marcus Davidsson; Gang Wang; Patrick Aldrin-Kirk; Morgan Hartnor; Tomas Björklund;
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1. CNS-directed AAV2-mediated gene therapy ameliorates functional deficits in a murine model of infantile neuronal ceroid lipofuscinosis. [J] . Griffey MA, Wozniak D, Wong M, Molecular therapy: the journal of the American Society of Gene Therapy . 2006,第3期

机译：CNS指导的AAV2介导的基因治疗可改善婴儿神经元类固醇脂褐藻病的小鼠模型中的功能缺陷。
2. Adeno-Associated Virus (AAV) Serotype 9 Provides Global Cardiac Gene Transfer Superior to AAV1, AAV6, AAV7, and AAV8 in the Mouse and Rat [J] . Lawrence T. Bish Kevin Morine Meg M. Sleeper Julio Sanmiguel Di Wu Guangping Gao James M. Wilson H. Lee Sweeney. Human Gene Therapy . 2008,第12期

机译：腺相关病毒（AAV）血清型9在小鼠和大鼠中提供优于AAV1，AAV6，AAV7和AAV8的全局心脏基因转移
3. Adeno-Associated Virus (AAV) Serotype 9 ProvidesGlobal Cardiac Gene Transfer Superior to AAV1,AAV6, AAV7, and AAV8 in the Mouse and Rat [J] . Lawrence T. Bish, Kevin Morine, Meg M. Sleeper, Human gene therapy . 2008,第12期

机译：腺相关病毒（AAV）血清型9在小鼠和大鼠中提供优于AAV1，AAV6，AAV7和AAV8的全局心脏基因转移
4. MACT (Mosaicism with AAV Mediated Conditional Transgenesis) for Single Neuron Analysis of Neurodegeneration in Vivo, a Proof of Principle in Focal Cerebral Ischemia [C] . Madison Wynne El-Saadi, Laura Rivers, Xinli Tian, Southern Biomedical Engineering Conference . 2016

机译：MACT（与AAV介导的条件转基因的镶嵌关系）用于体内神经变性的单神经元分析，这是局灶性脑缺血的原理证明
5. Immunological and Biochemical Evaluation of the AAV Capsid to Advance Next-generation Gene Therapy Vector Design [D] . Giles, April Rose. 2018

机译：AAV Capsid推进下一代基因治疗载体设计的免疫和生化评价
6. Adeno-Associated Virus (AAV) Serotype 9 Provides Global Cardiac Gene Transfer Superior to AAV1 AAV6 AAV7 and AAV8 in the Mouse and Rat [O] . Lawrence T. Bish, Kevin Morine, Meg M. Sleeper, -1

机译：腺相关病毒（AAV）血清型9在小鼠和大鼠中提供优于AAV1AAV6AAV7和AAV8的全局心脏基因转移
7. 548. Recombinant AAV3 Serotype Vectors Generated by Using AAV3 ITRs and AAV3 Rep Proteins Efficiently Transduce Human Liver Cancer Cell Lines In Vitro and Human Liver Tumors in a Murine Xenograft Model In Vivo [O] . Pediatrics, University of Florida College of Medicine, Gainesville, FL ( host institution ), Ling, Chen ( UF author ), Yin, Zifei ( author ), 2016

机译：548.通过使用AAV3 ITR和AAV3 Rep蛋白产生的重组AAV3血清型载体在小鼠异种移植模型体内有效地体外转导人肝癌细胞系和人肝肿瘤。

542. Novel Barcode-Based In Vivo Screening Method for Generating De Novo AAV Serotypes for CNS-Directed Gene Therapy

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