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Substituted 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidines Are Highly Active CDK9 Inhibitors: Synthesis, X-ray Crystal Structures, Structure–Activity Relationship, and Anticancer Activities

机译：取代的4-（噻唑-5-基）-2-（苯氨基）嘧啶是高活性CDK9抑制剂：合成，X射线晶体结构，结构 - 活性关系和抗癌活动

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Hao Shao; Shenhua Shi; Shiliang Huang; Alison J. Hole; Abdullahi Y. Abbas; Sonja Baumli; Xiangrui Liu; Frankie Lam; David W. Foley; Peter M. Fischer; Martin Noble; Jane A. Endicott; Chris Pepper; Shudong Wang;
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1. Substituted 4-(thiazol-5-yl)-2-(phenylamino)pyrimidines are highly active CDK9 inhibitors: Synthesis, X-ray crystal structures, structure-activity relationship, and anticancer activities [J] . Shao H., Shi S., Huang S., Journal of Medicinal Chemistry . 2013,第3期

机译：取代的4-（噻唑-5-基）-2-（苯氨基）嘧啶类是高度活性的CDK9抑制剂：合成，X射线晶体结构，结构活性关系和抗癌活性
2. Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro- N 2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)- N 4-(2-(isopropylsulfonyl) phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials [J] . Marsilje T.H., Pei W., Chen B., Journal of Medicinal Chemistry . 2013,第14期

机译：新型有效和选择性间变性淋巴瘤激酶（ALK）抑制剂5-氯-N 2-（2-异丙氧基-5-甲基-4-（哌啶-4-基）苯基）的合成，构效关系和体内功效）-N 4-（2-（异丙基磺酰基）苯基）嘧啶-2,4-二胺（LDK378）目前处于1期和2期临床试验中
3. Tyrosine kinase inhibitors. 14. Structure-activity relationships for methylamino-substituted derivatives of 4-((3-bromophenyl)amino)-6-(methylamino)-pyrido(3,4-d)pyrimidine (PD 158780), a potent and specific inhibitor of the tyrosine kinase activity [J] . Rewcastle GW, Murray DK, Elliott WL, Journal of Medicinal Chemistry . 1998,第5期

机译：酪氨酸激酶抑制剂。 14. 4-（（3-溴苯基）氨基）-6-（甲基氨基）-吡啶基（3,4-d）嘧啶（PD 158780）的甲基氨基取代衍生物的结构活性关系（PD 158780）酪氨酸激酶活性
4. Structure-activity relationships of 2-substituted androsta-1,4-diene-3,17-diones as aromatase inhibitors [C] . Takahashi M., Ha W., Umeta H., International Conference on Cytochrome P450 . 2009

机译：2-取代的androsta-1,4-二烯-3,17-致芳香酶抑制剂的结构 - 活性关系
5. A structure-activity approach to drug action in pharmacology: (A) Structure-activity relationships involved in DT-diaphorase (NQO1) mediated reduction kinetics and mode of action of anticancer bioreductive benzoquinone alkylating agents. (B) Structural characteristics of novel NMDA receptor antagonists required for renal tubule organic cation secretion . [D] . Fourie, Jeanne. 2004

机译：一种在药理学中用于药物作用的结构活性方法：（A）DT-黄递酶（NQO1）介导的抗癌生物还原苯醌烷基化剂的还原动力学和作用方式的结构活性关系。（B）肾小管有机阳离子分泌所需的新型NMDA受体拮抗剂的结构特征。
6. Substituted 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidinesAre Highly Active CDK9 Inhibitors: Synthesis X-ray CrystalStructures Structure–Activity Relationship and AnticancerActivities [O] . Hao Shao, Shenhua Shi, Shiliang Huang, -1

机译：取代的4-（噻唑-5-基）-2-（苯氨基）嘧啶是高活性CDK9抑制剂：合成X射线晶体结构结构-活性关系和抗癌活动项目
7. Novel Potent Orally Active Selective VEGFR-2 Tyrosine Kinase Inhibitors: Synthesis, Structure-Activity Relationships, and Antitumor Activities of N-Phenyl-N-{4-(4-quinolyloxy)phenyl}ureas [O] . -1

机译：新型有效口服活性选择性选择性VEGFR-2酪氨酸激酶抑制剂：N-苯基-N- {4-（4-喹啉氧基）苯基}脲的合成，结构活性关系和抗肿瘤活性

Substituted 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidines Are Highly Active CDK9 Inhibitors: Synthesis, X-ray Crystal Structures, Structure–Activity Relationship, and Anticancer Activities

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