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Development of a Pharmacodynamic Assay Based on PLCγ2 Phosphorylation for Quantifying Spleen Tyrosine Kinase (SYK)–Bruton’s Tyrosine Kinase (BTK) Signaling

机译：基于PLCγ2磷酸化对量化脾酪氨酸激酶（SYK）-BRUTON酪氨酸激酶（BTK）信号传导的药物动力学测定

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Jonathan Hsu; Jun Zhang; Chris Kitson; Seng-Lai Tan; Satwant Narula; Julie A. DeMartino; Cheng Liao;
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年度 2013
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1. Development of a pharmacodynamic assay based on PLCγ2 phosphorylation for quantifying spleen tyrosine kinase (SYK)-bruton's tyrosine kinase (BTK) signaling [J] . Hsu J., Zhang J., Kitson C., Journal of biomolecular screening: The official journal of the Society for Biomolecular Screening . 2013,第8期

机译：基于PLCγ2磷酸化的药效学测定方法的开发，用于定量脾酪氨酸激酶（SYK）-布鲁顿酪氨酸激酶（BTK）信号传导
2. Antiarthritis effect of a novel Bruton's tyrosine kinase (BTK) inhibitor in rat collagen-induced arthritis and mechanism-based pharmacokinetic/pharmacodynamic modeling: relationships between inhibition of BTK phosphorylation and efficacy. [J] . Liu L, Di Paolo J, Barbosa J, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2011,第1期

机译：新型Bruton酪氨酸激酶（BTK）抑制剂在大鼠胶原诱导的关节炎中的抗关节炎作用和基于机理的药代动力学/药效学模型：抑制BTK磷酸化与功效之间的关系。
3. The Activating C-type Lectin-like Receptor NKp65 Signals through a Hemi-immunoreceptor Tyrosine-based Activation Motif (hemITAM) and Spleen Tyrosine Kinase (Syk) [J] . Bj?rn Bauer, Tanja Wotapek, Tobias Z?ller, The Journal of biological chemistry . 2017,第8期

机译：激活的C型凝集素样受体NKp65信号通过基于半免疫受体酪氨酸的活化基序（hemITAM）和脾酪氨酸激酶（Syk）
4. Activation State of Primary Human B Cells Measured by Quantitation of Phosphorylation on Syk Kinase Linker Region Tyrosines [C] . Anita Izrael-Tomasevic, Andrew C. Vendel, Jill Calemine-Fenaux, ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：通过在Syk激酶接头区域酪氨酸上定量磷酸化测量的初级人B细胞的激活状态
5. An RNAi screen targeting the protein tyrosine kinases identifies Bruton's tyrosine kinase (BTK) as a breast cancer cell survival factor. [D] . Eifert, Cheryl. 2009

机译：靶向蛋白质酪氨酸激酶的RNAi筛选可将布鲁顿酪氨酸激酶（BTK）识别为乳腺癌细胞生存因子。
6. The Activating C-type Lectin-like Receptor NKp65 Signals through a Hemi-immunoreceptor Tyrosine-based Activation Motif (hemITAM) and Spleen Tyrosine Kinase (Syk) [O] . Björn Bauer, Tanja Wotapek, Tobias Zöller, 2017

机译：通过基于半免疫受体酪氨酸的活化基序（hemITAM）和脾酪氨酸激酶（Syk）激活C型凝集素样受体NKp65信号。
7. The Activating C-type Lectin-like Receptor NKp65 Signals through a Hemi-immunoreceptor Tyrosine-based Activation Motif (hemITAM) and Spleen Tyrosine Kinase (Syk) [O] . Björn Bauer, Tanja Wotapek, Tobias Zöller, 2017

机译：通过基于Hemi-ImmuneCeptor酪氨酸的活化基序（血红蛋白）和脾酪氨酸激酶（Syk）激活C型凝集素样受体NKP65信号

Development of a Pharmacodynamic Assay Based on PLCγ2 Phosphorylation for Quantifying Spleen Tyrosine Kinase (SYK)–Bruton’s Tyrosine Kinase (BTK) Signaling

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