首页> 外文OA文献 >A.actinomycetemcomitans adhesi protein increasing IL-8 titre in heart of wistar rat with aggressive periodontitis (Protein adhesin dari A.actinomycetemcomitans meningkatkantiter IL -8 di dalamjantungtikuswistar denganperiodontitis agresif)
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A.actinomycetemcomitans adhesi protein increasing IL-8 titre in heart of wistar rat with aggressive periodontitis (Protein adhesin dari A.actinomycetemcomitans meningkatkantiter IL -8 di dalamjantungtikuswistar denganperiodontitis agresif)

机译:A.ActinomycetemcoMitans粘附蛋白增加IL-8滴度在Wistar大鼠心脏中,具有激进的牙周炎(来自Actinomycetemco1的蛋白质粘附蛋白增加了Titiger IL-8在Hantingtikus Wistar的抗癌性炎)

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摘要

Cardiovascular and periodontal diseases are common inflammatory conditions in the human population. Tlymphocytesparticipateinthepathogenesis and inflammatory events of atherosclerosis. These immune cells enter theinflamed artery wall and join macrophages via a number of interferon-c-inducible chemokines. Chemokines (IL-8),cytokines, and growth factors also participate in this process. The interaction between interleukin- 8 and its receptor,CXCR2, can also contribute to lesion formation in mice. The main causes of aggressive periodontitis isActinobacillusactinomycetemcomitans. Previous studies have proven that adhesin protein with 24 kDa molecular weight from A.actinomycetemcomitans is a specific adhesin, this adhesin proteins play a role in the adhesion process on host. thiskind adhesion in the epithelial attachment would lead to colonization and invasion ofA.actinomycetemcomitans thatwill stimulate the host immune response. This study aimed to analyze the influence of induction 24 kDaA.actinomycetemcomitans adhesin protein to the titre of IL-8 in heart of Wistar rat with aggressive periodontitis usingElisa method to measure and analyze the titre of IL-8. After analyzed with analysis of variance, showed significantdifferences of IL-8 titre in the control group and the group with the induction byA.actinomycetemcomitans,A.actinomycetemcomitans plus 24 kDa A.actinomycetemcomitans adhesin protein, and only with 24 kDaA.actinomycetemcomitans adhesin protein. It can be concluded that A.actinomycetemcomitans adhesin protein with 24kDa molecular weight has a role in increasing of IL-8 titre in heart wistar rat with aggressive periodontitis.
机译:心血管和牙周病是人口中常见的炎症病症。 tlymphocytesparticipateinthepathogenesis和动脉粥样硬化的炎症事件。这些免疫细胞进入诸如干扰素-C-C-诱导趋化因子的促血管壁并加入巨噬细胞。趋化因子(IL-8),细胞因子和生长因素也参与了这一过程。白细胞介素-8及其受体之间的相互作用CXCR2也可以有助于小鼠的病变形成。侵袭性牙周炎isactinobacillusactInomycetemoLans的主要原因。先前的研究已经证明,来自A.Actinycetemco1的24kDa分子量的粘合剂蛋白是一种特定的粘合剂,这种粘合剂蛋白在宿主上的粘附过程中起作用。在上皮附着的同步粘附会导致殖民化和侵袭。作用刺激宿主免疫应答的术术。本研究旨在分析诱导24 kdaa.Actinomycetemco1的影响,在Wistar大鼠心脏滴注中的IL-8滴度,用辐射牙周炎测量和分析IL-8的滴度。在分析方差分析后,在对照组中显示出IL-8滴度的显着性,并且具有诱导BYA.ActinomycetemcoNIs,A.ActinomycetemcoNInans以及24kDaA.ActinomycetemcoNs粘附蛋白,并且仅含有24kdaa.actinomycetemcoMentans的粘合剂蛋白。可以得出结论,具有24KDA分子量的粘液蛋白蛋白蛋白质在随着侵袭性牙周炎的心脏Wistar大鼠中增加IL-8滴度的作用。

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