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The Role of DNA Degradation in the Estimation of Post-Mortem Interval: A Systematic Review of the Current Literature

机译:DNA降解在验尸间隔估计中的作用:对当前文献的系统审查

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摘要

The determination of the post-mortal interval (PMI) is an extremely discussed topic in the literature and of deep forensic interest, for which various types of methods have been proposed. The aim of the manuscript is to provide a review of the studies on the post-mortem DNA degradation used for estimating PMI. This review has been performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and the PRISMA Guidelines. Several analytical techniques have been proposed to analyse the post-mortem DNA degradation in order to use it to estimate the PMI. Studies focused mainly on animal models and on particular tissues. The results have been mixed: while on the one hand literature data in this field have confirmed that in the post-mortem several degradation processes involve nucleic acids, on the other hand some fundamental aspects are still little explored: the influence of ante and post-mortem factors on DNA degradation, the feasibility and applicability of a multiparametric mathematical model that takes into account DNA degradation and the definition of one or more target organs in order to standardize the results on human cases under standard conditions.
机译:致命间隔(PMI)的确定是文献中的一个极其讨论的主题,并提出了各种类型的方法。稿件的目的是提供对用于估算PMI的验尸DNA降解研究的研究综述。此评价已在系统评价和荟萃分析和PRISMA指南中进行的首选报告项目进行了执行。已经提出了几种分析技术来分析验尸后DNA劣化以便使用它来估计PMI。研究主要集中在动物模型和特定组织上。结果已经混合:虽然在这一领域的一方面文学数据中证实,在验尸后几种降解过程涉及核酸,另一方面仍然很少探索:蚂蚁和后的影响对DNA降解的验证因素,多次数数学模型的可行性和适用性考虑了DNA降解和一个或多个靶器官的定义,以便在标准条件下标准化人类病例的结果。

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