首页> 外文OA文献 >Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)–A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer’s Disease

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Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)–A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer’s Disease

机译：发现3-亚氨基-1,2,4-噻二嗪烷酮1,1-二氧化锑衍生物（MK-8931）-Aβ-位点淀粉样蛋白前体蛋白切割酶1抑制阿尔茨海默病的抑制剂

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Jack D. Scott; Sarah W. Li; Andrew P. J. Brunskill; Xia Chen; Kathleen Cox; Jared N. Cumming; Mark Forman; Eric J. Gilbert; Robert A. Hodgson; Lynn A. Hyde; Qin Jiang; Ulrich Iserloh; Irina Kazakevich; Reshma Kuvelkar; Hong Mei; John Meredith; Jeffrey Misiaszek; Peter Orth; Lana M. Rossiter; Meagan Slater; Julie Stone; Corey O. Strickland; Johannes H. Voigt; Ganfeng Wang; Hongwu Wang; Yusheng Wu; William J. Greenlee; Eric M. Parker; Matthew E. Kennedy; Andrew W. Stamford;
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1. Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer's Disease [J] . Scott Jack D., Li Sarah W., Brunskill Andrew P. J., Journal of Medicinal Chemistry . 2016,第23期

机译：发现3-Imino-1,2,4-噻二嗪1,1-二氧化物衍生物Verubecestat（MK-8931）-A-Site淀粉样前体蛋白裂解酶1抑制剂用于治疗阿尔茨海默氏病
2. Critical analysis of the use of β-site amyloid precursor protein-cleaving enzyme 1 inhibitors in the treatment of Alzheimer's disease [J] . Genevieve Evin, Adel Barakat Degenerative Neurological and Neuromuscular Disease . 2014,第2003期

机译：使用β-位淀粉样蛋白前体蛋白裂解酶1抑制剂治疗阿尔茨海默氏病的关键分析
3. Arylbenzofurans from the Root Bark of Morus alba as Triple Inhibitors of Cholinesterase, β-Site Amyloid Precursor Protein Cleaving Enzyme 1, and Glycogen Synthase Kinase-3β: Relevance to Alzheimer’s Disease [J] . Pradeep Paudel, Su Hui Seong, Yajuan Zhou, ACS Omega . 2019,第4期

机译：桑树根皮中的芳基苯并呋喃作为胆碱酯酶，β-位淀粉样前体蛋白裂解酶1，糖原合酶激酶-3β的三重抑制剂：与阿尔茨海默氏病的相关性
4. Active site cavities identification of amyloid beta precursor protein: Alzheimer disease study [C] . P. RajaRajeswari, S. Viswanadha Raju, Amira S. Ashour, 20th Jubilee IEEE International Conference on Intelligent Engineering Systems . 2016

机译：淀粉样β前体蛋白的活动部位腔鉴定：阿尔茨海默氏病研究
5. Role of amyloid precursor protein and amyloid-beta in Alzheimer's disease: Modulation of APP processing detection of Abeta oligomers, and their role in the pathogenesis and treatment of AD. [D] . Kim, Minkyu Leo. 2009

机译：淀粉样前体蛋白和淀粉样β在阿尔茨海默氏病中的作用：APP处理Abeta寡聚体检测的调节及其在AD的发病机理和治疗中的作用。
6. Critical analysis of the use of β-site amyloid precursor protein-cleaving enzyme 1 inhibitors in the treatment of Alzheimer’s disease [O] . Genevieve Evin, Adel Barakat 2014

机译：使用β-位淀粉样蛋白前体蛋白裂解酶1抑制剂治疗阿尔茨海默氏病的关键分析
7. β-site amyloid precursor protein-cleaving enzyme 1(BACE1) inhibitor treatment induces Aβ5-X peptides through alternative amyloid precursor protein cleavage [O] . Erik Portelius, Robert A Dean, Ulf Andreasson, 2014

机译：β位淀粉样蛋白前体蛋白裂解酶1（BACE1）抑制剂处理通过替代性淀粉样蛋白前体蛋白裂解诱导Aβ5-X肽

Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)–A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer’s Disease

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