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Prediction of Tissue-Plasma Partition Coefficients Using Microsomal Partitioning: Incorporation into Physiologically based Pharmacokinetic Models and Steady-State Volume of Distribution Predictions

机译：使用微粒体分配的组织 - 血浆分区系数预测：在生理基于药代动力学模型中的掺入分布预测

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Kimberly Holt; Min Ye; Swati Nagar; Ken Korzekwa;
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1. Prediction of Tissue-Plasma Partition Coefficients Using Microsomal Partitioning: Incorporation into Physiologically based Pharmacokinetic Models and Steady-State Volume of Distribution Predictions [J] . Holt Kimberly, Ye Min, Nagar Swati, Drug Metabolism and Disposition: The Biological Fate of Chemicals . 2019,第10期

机译：使用微粒体分配的组织 - 血浆分区系数预测：掺入生理基于药代动力学模型和分布预测的稳态体积
2. Prediction of the volume of distribution of a drug: which tissue-plasma partition coefficients are needed? [J] . Bjorkman S, poteket.Se Journal of Pharmacy and Pharmacology . 2002,第9期

机译：药物分布量的预测：需要哪些组织-血浆分配系数？
3. A priori prediction of tissue:plasma partition coefficients of drugs to facilitate the use of physiologically-based pharmacokinetic models in drug discovery. [J] . Poulin P, Theil FP Journal of pharmaceutical sciences. . 2000,第1期

机译：药物的组织：血浆分配系数的先验预测，以利于在药物发现中使用基于生理的药代动力学模型。
4. Application of the Conduct-like Screening Models for Real Solvent and Segment Activity Coefficient for the Predictions of Partition Coefficients and Vapor-Liquid and Liquid-Liquid Equilibria of Bio-oil-Related Mixtures [C] . Jinlong Li, Patrice Paricaud International Conference Petroleum Phase Behavior and Fouling . 2012

机译：用于实际溶剂和分段活性系数的电导样筛选模型的应用，用于预测分配系数和汽液和液液与生物油相关混合物的液体液体平衡
5. Evaluation of Different In Vitro Surrogates to Represent Nonspecific Binding for Tissue: Plasma Water Partition Coefficient Predictions [D] . Holt, Kimberly L. 2019

机译：不同体外替代物的评价表示组织的非特异性结合：等离子体水分配系数预测
6. Use of partition coefficients in flow-limited physiologically-based pharmacokinetic modeling [O] . Matthew D. Thompson, Daniel A. Beard, Fan Wu -1

机译：在流动的基于生理学药代理建模中使用分区系数
7. Use of partition coefficients in flow-limited physiologically-based pharmacokinetic modeling [O] . Matthew D. Thompson, Daniel A. Beard, Fan Wu 2012

机译：在流动的基于生理学药代理建模中使用分区系数
8. Analysis of Algorithms Predicting Blood: Air and Tissue: Blood Partition Coefficient from Solvent Partition Coefficients for Use in Complex Mixture Physiological Based Pharmacokinetic/Pharmacodynamic Modeling [R] . Sterner, T. R. , Robinson, P. J. , Mattie, D. R. , 2004

机译：预测血液的算法分析：空气和组织：用于复杂混合物的溶剂分配系数的血液分配系数基于生理学的药代动力学/药效学模型

Prediction of Tissue-Plasma Partition Coefficients Using Microsomal Partitioning: Incorporation into Physiologically based Pharmacokinetic Models and Steady-State Volume of Distribution Predictions

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