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Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A

机译：缺陷的内部变构网络赋予蛋白激酶A的致癌嵌合体中的功能障碍ATP /底物结合合作

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Cristina Olivieri; Caitlin Walker; Adak Karamafrooz; Yingjie Wang; V. S. Manu; Fernando Porcelli; Donald K. Blumenthal; David D. Thomas; David A. Bernlohr; Sanford M. Simon; Susan S. Taylor; Gianluigi Veglia;
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1. Phosphorylation of recombinant human ATP:citrate lyase by cAMP-dependent protein kinase abolishes homotropic allosteric regulation of the enzyme by citrate and increases the enzyme activity. Allosteric activation of ATP:citrate lyase by phosphorylate [J] . Potapova IA, El Maghrabi-MR, Doronin SV, Biochemistry . 2000,第5期

机译：cAMP依赖性蛋白激酶将重组人ATP：柠檬酸裂合酶磷酸化，消除了柠檬酸对酶的同构变构调节，并增加了酶活性。磷酸对ATP：柠檬酸裂解酶的变构活化
2. Discovery of Bifunctional Oncogenic Target Inhibitors against Allosteric Mitogen-Activated Protein Kinase (MEK1) and Phosphatidylinositol 3-Kinase (PI3K) [J] . Van Dort Martian E., Hong Hao, Wang Hanxiao, Journal of Medicinal Chemistry . 2016,第6期

机译：发现双功能致癌性靶向抑制剂的变构丝裂原激活的蛋白激酶（MEK1）和磷脂酰肌醇3-激酶（PI3K）。
3. Dual inhibition of allosteric mitogen-activated protein kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) oncogenic targets with a bifunctional inhibitor [J] . Van Dort Marcian E., Galban Stefanie, Wang Hanxiao, Bioorganic and medicinal chemistry . 2015,第7期

机译：用双功能抑制剂双重抑制变构分裂原活化蛋白激酶（MEK）和磷脂酰肌醇3激酶（PI3K）致癌靶标
4. A Collision Induced Unfolding Assay for Dierentiating ATP-Competitive and Allosteric Protein Tyrosine Kinase Inhibitors [C] . James E. Keating, Jessica N. Rabuck-Gibbons, Brandon T. Ruotolo ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：针对ATP竞争性和颠振蛋白酪氨酸激酶抑制剂的固化性诱导诱导展开测定
5. Role of Oncogenic Protein Kinase C-iota in Melanoma Progression; A Study Based on Atypical Protein Kinase-C Inhibitors [D] . Ratnayake, Wishrawana Sarathi Bandara. 2019

机译：致癌蛋白激酶C-IOTA在黑色素瘤进展中的作用; 基于非典型蛋白激酶-C抑制剂的研究
6. Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A [O] . Cristina Olivieri, Caitlin Walker, Adak Karamafrooz, 2021

机译：缺陷的内部变构网络赋予蛋白激酶A的致癌嵌合体中的功能障碍ATP /底物结合合作
7. Dual inhibition of allosteric mitogen-activated protein kinase (MEK) and phosphatidylinositol 3-kinase (PI3K) oncogenic targets with a bifunctional inhibitor [O] . Marcian E. Van Dort, Stefanie Galbán, Hanxiao Wang, 2015

机译：用双官能抑制剂对抗蛋白酶激活蛋白激酶（MEK）和磷脂酰肌醇3-激酶（PI3K）致癌靶的双重抑制

Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A

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