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Genetic and Environmental Influences on Developmental Milestones and Movement: Results From the Gemini Cohort Study

机译:关于发展里程碑和运动的遗传和环境影响:双子座队列研究结果

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摘要

Purpose: Variability in the timing of infant developmental milestones is poorly understood. We used a twin analysis to estimate genetic and environmental influences on motor development and activity levels in infancy. Method: Data were from the Gemini Study, a twin birth cohort of 2,402 families with twins born in the United Kingdom in 2007. Parents reported motor activity level for each of the twins at age 3 months using the Revised Infant Behavior Rating Scale and reported the ages at which they first sat unsupported, crawled, and walked unaided. Results: Activity level at 3 months and ages when first sitting and crawling were about equally influenced by the shared family environment (45%–54%) and genes (45%–48%). Genetic influences dominated for age when children took their first independent steps (84%). Conclusion: Aspects of the shared family environment appear to be important influences on motor activity levels and early milestones, although the timing of walking may have a stronger genetic influence. Further research to identify the specific environmental and genetic factors that promote early activity may be important for longer-term health outcomes.
机译:目的:婴儿发育里程碑时机的变化很差。我们利用双胞胎分析来估算初期电机开发和活动水平的遗传和环境影响。方法:数据来自双子研究,2402个家庭与出生于英国,2007年父母双胞胎双胞胎出生队列报道在3月龄为每对双胞胎的运动活动水平使用经修订的婴幼儿行为评定量表和报道他们第一次坐着不受支持,爬行并努力走路。结果:第一次坐着和爬行时,活动水平在3个月和年龄受共用家庭环境(45%-54%)和基因的同样影响(45%-48%)。当孩子们采取第一个独立步骤(84%)时,遗传影响为年龄占年龄。结论:共享家庭环境的方面似乎对运动活动水平和早期里程碑的重要影响,尽管步行的时机可能具有更强的遗传影响。进一步的研究,以确定促进早期活动的特定环境和遗传因素可能对长期健康结果很重要。

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