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Novel PAC1 receptor antagonists alleviate paclitaxel-induced mechanical allodynia by inhibiting astrocytic activation

机译：新型PAC1受体拮抗剂通过抑制星形胶质性活化来减轻紫杉醇诱导的机械异常性疼痛

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Arata Inoue; Takuya Okada; Naoki Toyooka; Hiroaki Goda; Atsuro Miyata; Takashi Kurihara; Ichiro Takasaki;
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1. Spinal astrocytic activation contributes to both induction and maintenance of pituitary adenylate cyclase-activating polypeptide type 1 receptor-induced long-lasting mechanical allodynia in mice [J] . Masafumi Yokai, Takashi Kurihara, Atsuro Miyata Molecular pain . 2016,第1期

机译：脊髓星形胶质细胞激活有助于诱导和维持垂体腺苷酸环化酶激活多肽1型受体诱导的小鼠持久机械异常性疼痛
2. The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CB₂ receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy [J] . Liting Deng, Josée Guindon, V Kiran Vemuri, Molecular pain . 2012,第2期

机译：大麻素CB _{2 受体的激活抑制了顺铂和紫杉醇诱导的机械性和冷性异常性疼痛的维持，并且在化学疗法诱导的周围神经病模型中独立于CXCR4信号传导}
3. Danhong Injection Alleviates Mechanical Allodynia via Inhibiting ERK1/2 Activation and Elevates BDNF Level in Sciatic Nerve in Diabetic Rat [J] . Qi Wang, Zhuang-Li Guo, Ge-Le Aori, Evidence-based complementary and alternative medicine: eCAM . 2018,第7期

机译：丹红注射液通过抑制ERK1 / 2活化减轻机械性痛觉过敏，并提高糖尿病大鼠坐骨神经中BDNF的水平
4. Alleviation of mechanical allodynia by the inhibition of microglial interleukin-18 in the spinal cord [C] . Chu Yu-Xia, Xin-Mei Zhou, Min Wang, 2011 International Conference on Remote Sensing, Environment and Transportation Engineering . 2011

机译：通过抑制脊髓中的小胶质细胞IL-18减轻机械性痛觉过敏
5. Bi-directional astrocyte-neuron signaling in the hippocampus: Gq-coupled receptor activation mediates astrocytic calcium ion and purinergic gliotransmission. [D] . Kubera, Cathryn Laura. 2008

机译：海马中的双向星形胶质细胞-神经元信号传导：Gq耦合受体激活介导星形细胞钙离子和嘌呤能神经胶质传递。
6. Spinal astrocytic activation contributes to both induction and maintenance of pituitary adenylate cyclase-activating polypeptide type 1 receptor-induced long-lasting mechanical allodynia in mice [O] . Masafumi Yokai, Takashi Kurihara, Atsuro Miyata 2016

机译：脊髓星形胶质细胞激活有助于诱导和维持垂体腺苷酸环化酶激活多肽1型受体诱导的小鼠持久机械异常性疼痛
7. Spinal astrocytic activation contributes to both induction and maintenance of pituitary adenylate cyclase-activating polypeptide type 1 receptor-induced long-lasting mechanical allodynia in mice [O] . Masafumi Yokai, Takashi Kurihara, Atsuro Miyata 2016

机译：脊髓星形织造菌激活有助于垂体腺苷酸环酶激活多肽1型受体诱导的小鼠持久的持久性机械异常疼痛的诱导和维持
8. G Protein Coupled Receptor (GPCR) Agonists and Antagonists and Methods of Activating and Inhibiting GPCR Using the Same. [R] . Kuliopulos, A., Covic, L. 2005

机译：G蛋白偶联受体（GpCR）激动剂和拮抗剂以及使用它们激活和抑制GpCR的方法。

Novel PAC1 receptor antagonists alleviate paclitaxel-induced mechanical allodynia by inhibiting astrocytic activation

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