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Helicobacter pylori infection rates in dyspeptic Serbian HIV-infected patients compared to HIV-negative controls

机译:幽门螺杆菌感染率在消化不良塞尔维亚艾滋病毒感染患者中,与HIV阴性对照相比

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摘要

Helicobacter pylori infection does not belong to the spectrum of opportunistic infections in people living with HIV (PLHIV). To evaluate the Helicobacter pylori infection prevalence rate trends in HIV co-infected individuals in comparison to the HIV-negative population, we compared histopathological findings of H. pylori positive gastritis (gastritis topography and histopathology) between 303 PLHIV and 2642 HIV-negative patients who underwent esophagogastroduodenoscopy (EGD) between 1993 and 2014 due to dyspeptic symptoms. The prevalence of H. pylori infection was significantly higher in HIV-negative controls than in PLHIV (50.2% vs. 28.1%). A significantly positive linear trend of H. pylori co-infection in PLHIV was revealed in the observed period (b = 0.030, SE = 0.011, p = 0.013), while this trend was significantly negative in HIV-negative patients (b = - 0.027, SE = 0.003, p < 0.001). Patients with HIV/H. pylori co-infection had significantly higher CD4+ T cell counts and more often had undetectable HIV viremia, due to successful anti-retroviral therapy (ART). Stomach histopathological findings differed between HIV co-infected and H. pylori mono-infected patients. Our findings confirm that the ART has changed the progression of HIV infection, leading to a significant increase in the prevalence of H. pylori infection in dyspeptic PLHIV over time. Our data also suggests that a functional immune system may be needed for H. pylori-induced human gastric mucosa inflammation.
机译:幽门螺杆菌感染不属于艾滋病毒(Plhiv)的人们的机会感染谱。为了评估幽门螺杆菌感染率相比,与艾滋病毒阴性群体相比,我们对幽门螺杆菌阳性胃炎(胃炎地形和组织病理学)的组织病理学发现进行了比较了303 plhiv和2642名HIV阴性患者的组织病理学发现由于消化不良症状,1993年至2014年间受到食管古典综合症(EGD)。 HIV阴性对照的患病率显着高于PLHIV(50.2%vs.28.1%)。在观察期(B = 0.030,SE = 0.011,P = 0.013)中,揭示了PLHIV中幽门螺杆菌的显着阳性线性趋势。 ,se = 0.003,p <0.001)。患有HIV / h的患者。由于成功的抗逆转录病毒治疗(ART),Pylori Co-cocts患者的CD4 + T细胞计数显着更高,并且更常常具有未检测到的艾滋病毒毒性血症。胃组织病理学发现不同于艾滋病毒COM感染和H. Pylori单声道患者。我们的调查结果证实,本艺术改变了艾滋病毒感染的进展,导致幽门螺杆菌感染随着时间的推移缺血性的普遍性的显着增加。我们的数据还表明,H.Pylori诱导的人胃粘膜炎症可能需要功能性免疫系统。

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