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Structure−Activity Relationships Comparing N-(6-Methylpyridin-yl)-Substituted Aryl Amides to 2-Methyl-6-(substituted-arylethynyl)pyridines or 2-Methyl-4-(substituted-arylethynyl)thiazoles as Novel Metabotropic Glutamate Receptor Subtype 5 Antagonists

机译：将N-（6-甲基吡啶-YL） - 取出的芳基酰胺与2-甲基-6-（取代芳基乙炔基）吡啶或2-甲基-4-（取代芳基乙炔基）噻唑进行比较的结构 - 活性关系作为新的代谢谷氨酸受体亚型5个拮抗剂

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Santosh S. Kulkarni; Mu-Fa Zou; Jianjing Cao; Jeffrey R. Deschamps; Alice L. Rodriguez; P. Jeffrey Conn; Amy Hauck Newman;
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1. Structure-Activity Relationships Comparing N-(6-Methylpyridin-yl)-Substituted Aryl Amides to 2-Methyl-6-(substituted-arylethynyl)pyridines or 2-Methyl-4-(substituted-arylethynyl)thiazoles as Novel Metabotropic Glutamate Receptor Subtype 5 Antagonists [J] . Kulkarni SS, Zou MF, Cao JJ, Journal of Medicinal Chemistry . 2009 ,第11期

机译：结构-活性关系比较N-（6-甲基吡啶基-基）取代的芳基酰胺与2-甲基-6-（取代-芳基乙炔基）吡啶或2-甲基-4-（取代-芳基乙炔基）噻唑为新型代谢型谷氨酸受体亚型5拮抗剂
2. The metabotropic glutamate receptor subtype 5 antagonist fenobam is analgesic and has improved in vivo selectivity compared with the prototypical antagonist 2-methyl-6-(phenylethynyl)-pyridine. [J] . Montana MC, Cavallone LF, Stubbert KK The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2009 ,第3期

机译：与原型拮抗剂2-甲基-6-（苯基乙炔基）-吡啶相比，代谢型谷氨酸受体亚型5拮抗剂芬诺班具有镇痛作用，并且具有更高的体内选择性。
3. Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5. [J] . Zhang P, Zou MF, Rodriguez AL, Bioorganic and medicinal chemistry . 2010 ,第9期

机译：在代谢型谷氨酸受体亚型5的一系列新的7-取代芳基喹啉和5-取代芳基苯并噻唑中的结构活性关系。
4. Synthesis of new glutamate receptor probes: I. Total synthesis of dysiherbaine, a potent glutamate receptor excitotoxin; II. Design and synthesis of dysiherbaine analogues; III. Synthesis and structure-activity relationships of substituted benzothiadiazides and their role as AMPA receptor modulators. [D] . Phillips, Dean Paul. 2001

机译：新型谷氨酸受体探针的合成：I. dysiherbaine的全合成，一种有效的谷氨酸受体兴奋性毒素；二。 dysiherbaine类似物的设计和合成；三，取代的苯并噻二叠氮化物的合成及其构效关系及其作为AMPA受体调节剂的作用。
5. Structure–Activity Relationships Comparing N-(6-Methylpyridin-yl)-Substituted Aryl Amides to 2-Methyl-6-(substituted-arylethynyl)pyridines or 2-Methyl-4-(substituted-arylethynyl)thiazoles as Novel Metabotropic Glutamate Receptor Subtype 5 Antagonists [O] . Santosh S. Kulkarni, Mu-Fa Zou, Jianjing Cao, -1

机译：结构 - 活性关系比较N-（6-甲基吡啶基）取代的芳基酰胺向2-甲基-6-（取代的 - 芳基乙炔）吡啶或2-甲基-4-（取代的 - 芳基乙炔）噻唑作为新型代谢型谷氨酸受体亚型5拮抗剂
6. The Metabotropic Glutamate Receptor Subtype 5 Antagonist Fenobam Is Analgesic and Has Improved in Vivo Selectivity Compared with the Prototypical Antagonist 2-Methyl-6-(phenylethynyl)-pyridine [O] . Montana, Michael C., Cavallone, Laura F., Stubbert, Kristi K., 2009

机译：代谢型谷氨酸受体亚型5拮抗剂苯巴比妥是与原型相比，镇痛药和体内选择性有所改善拮抗剂2-甲基-6-（苯基乙炔基）-吡啶

Structure−Activity Relationships Comparing N-(6-Methylpyridin-yl)-Substituted Aryl Amides to 2-Methyl-6-(substituted-arylethynyl)pyridines or 2-Methyl-4-(substituted-arylethynyl)thiazoles as Novel Metabotropic Glutamate Receptor Subtype 5 Antagonists

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