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Discrete Duration Models combining Dynamic and Random Effects. (REVISED, February 2000)

机译:结合动态和随机效果的离散持续时间模型。 (修订,2000年2月)

摘要

Survival data may include two different sources of variation, namely variation over time and variation over units. If both of these variations are present, neglecting one of them can cause serious bias in the estimations. Here we present an approach for discrete duration data that includes both time-varying and unit-specific effects to model the two mentioned variations simultaneously. The approach is a combination of the dynamic generalized linear model with dynamic time-varying baseline and covariate effects and the generalized linear mixed model measuring unobserved heterogeneity with random effects varying independently over units. Estimation is based on posterior modes, i.e., we maximize the joint posterior distribution of the unknown parameters to avoid numerical integration and simulation techniques, that are necessary in a full Bayesian analysis. Estimation of unknown hyperparameters is done by an EM-type algorithm. Finally, the proposed method is applied to data of the Veteran's Administration Lung Cancer Trial.
机译:生存数据可能包括两个不同的变化源,即随时间变化和随单位变化。如果同时存在这两种变化,则忽略其中之一可能会导致估计的严重偏差。在这里,我们提出了一种用于离散持续时间数据的方法,该方法既包含时变效果,又包含特定于单位的效果,以同时对上述两个变化进行建模。该方法是将动态广义线性模型与动态时变基线和协变量效应相结合,以及测量未观察到的异质性和随机效应随单位独立变化的广义线性混合模型的组合。估计基于后验模式,即我们将未知参数的联合后验分布最大化,以避免完整贝叶斯分析所需的数值积分和模拟技术。未知超参数的估计是通过EM型算法完成的。最后,将提出的方法应用于退伍军人管理局肺癌试验的数据。

著录项

  • 作者

    Biller Clemens;

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  • 年度 1997
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