ZrCl4-catalyzed C-O bond to C-N bond formation: synthesis of 1,2,3-triazoles and their biological evaluation

摘要

A simple and efficient protocol was developed for the synthesis of aryl azides directly from aryl carbinols using ZrCl4as a Lewis acid catalyst. The azides were converted to novel triazoles under click reaction conditions, which were evaluated for their antimicrobial activity against various strains.