Robust lumped-element modelling of centrifugo-pneumatic and siphon valving towards highly predictive simulation of large-scale integrated microfluidic networks

摘要

Drastic parameter reduction by lumped-element modelling by descriptors for flow control elements such as hydrodynamic resistance (“resistor”) pressure head (“voltage”) and flexible parts (“capacitance”) is the method of choice for simulating complex centrifugal microfluidic networks. As all liquid on such “Lab-on-a-Disc” (LoaD) systems are subject rotationally induced field, valving techniques are absolutely essential to orchestrate the serial release and processing of on-board samples and reagents