Lumped element simulation of a highly integrated bioanalytical centrifugal processing unit (“BioCPU”)

摘要

The centrifugal microfluidic platforms have evolved into a mature technology for a broad range of applications, for example in the life sciences, biomedical point-of-care diagnostics, and environmental monitoring. Whilst considerable progress has been made on functional elements of the Lab-on-a-Disc (LoaD) platform, the design of complex, highly integrated networks representing sample-to-answer automation of multi-step biochemical assays remains a significant challenge. This paper addresses a developed microfluidic simulation tool for the efficient layout, simulation and analysis of high performance LoaD systems implemented by featuring a novel, “digital” flow control scheme.