A fully automated wirelessly powered centrifugal platform towards a sample-to-answer chemiluminescent elisa assay for cvd detection

摘要

This paper describes the development of a platform where a silicon photo-multiplier (SiPM) sensor co-rotates with a “Lab-on-a-Disc” (LoaD). This platform includes a modular data-logger and, to avoid the need for electrical slip rings, it is wirelessly powered. This system is optimized for the detection of chemiluminescence. It is characterized on-disc using dilutions of HRP tagged antibodies and shows good agreement with a commercial luminometer. Additionally, preliminary work towards developing a fully integrated on-disc ELISA assay for CVD detection is presented.