Cytochrome P450 or high pH induce structural and functional changes of Coenzyme Q10

摘要

Coenzyme Q10 is a lipid soluble compound indispensable for optimal functioning of all living organisms, and it is the only non-protein in the mitochondrial electron transfer chain. Using voltammetry, UV-VIS spectrophotometry, EPR and NMR we have shown that Cytochrome P450 and high pH's induce structural and functional changes in Coenzyme Q10. The new derivative has much greater antioxidative potential and ability to bind Ca2+ and other earth-alkaline cations.