Freeze dried kit formulation of trastuzumab-immunoconjugates

摘要

Trastuzumab is a humanized anti-HER2 monoclonal antibody used for therapy of metastatic breast cancer. Conjugated antibodies with toxins, drugs and radionuclides, provide high hope for development of cancer-specific cytotoxic reagents. The formulation of stable immunoconjugates with a bifunctional chelators (BFCA) is required in order to obtain successful radiolabeling. The aim of this examination was to development a stable freeze dried trastuzumab immunoconjugates with BFCA p-SCN-Bn-DTPA, p-SCN-Bn-DOTA, 1B4M-DTPA.