Combined high contrast and wide field-of-view in the Scanning Laser Ophthalmoscope through dual detection of light paths

摘要

We demonstrate a multimode detection system in a scanning laser ophthalmoscope (SLO) thatudenables simultaneous operation in confocal, indirect, and direct modes to permit an agile trade between imageudcontrast and optical sensitivity across the retinal field of view to optimize the overall imaging performance,udenabling increased contrast in very wide-field operation. We demonstrate the method on a wide-field SLOudemploying a hybrid pinhole at its image plane, to yield a twofold increase in vasculature contrast in the centraludretina compared to its conventional direct mode while retaining high-quality imaging across a wide field of theudretina, of up to 200 deg and 20 μm on-axis resolution.