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Hippocampal damage and memory impairment in congenital cyanotic heart disease

机译:先天性紫绀型心脏病的海马损伤和记忆障碍

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摘要

Neonatal hypoxia can lead to hippocampal atrophy, which can lead, in turn, to memory impairment. To test the generalizability of this causal sequence, we examined a cohort of 41 children aged 8-16, who, having received the arterial switch operation to correct for transposition of the great arteries, had sustained significant neonatal cyanosis but were otherwise neurodevelopmentally normal. As predicted, the cohort had significant bilateral reduction of hippocampal volumes relative to the volumes of 64 normal controls. They also had significant, yet selective, impairment of episodic memory as measured by standard tests of memory, despite relatively normal levels of intelligence, academic attainment, and verbal fluency. Across the cohort, degree of memory impairment was correlated with degree of hippocampal atrophy suggesting that even as early as neonatal life no other structure can fully compensate for hippocampal injury and its special role in serving episodic long term memory.
机译:新生儿缺氧可导致海马萎缩,进而导致记忆障碍。为了检验此因果关系序列的一般性,我们检查了41名年龄在8-16岁之间的儿童,他们接受了动脉转换手术以纠正大动脉的移位,新生儿持续发significant,但神经发育正常。如预测的那样,该队列相对于64个正常对照的海马体积有明显的双侧减少。尽管他们的智力,学术水平和口语流利水平相对正常,但通过记忆标准测试测得的情节性记忆也有明显的但有选择性的损害。在整个队列中,记忆障碍的程度与海马萎缩的程度相关,这表明即使早在新生儿生命中,也没有其他结构可以完全补偿海马损伤及其在服务性长期记忆中的特殊作用。

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